A Low-Cost Wearable Connected Health Device for Monitoring Environmental Pollution Triggers of Asthma in Communities with Health Disparities

一种低成本可穿戴互联健康设备，用于监测健康差异社区中哮喘的环境污染诱因

• 批准号: 10601615
• 负责人: Krishna Naishadham
• 金额: $ 29.19万
• 依托单位: WI-SENSE, LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2024-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601615
• 关键词: Address; Adult; Affect; African American; African American population; Age; Air; Air Pollutants; Air Pollution; American; Area; Asthma; Atmosphere; Bluetooth; Calibration; Cellular Phone; Chemicals; Chronic Obstructive Pulmonary Disease; Code; Collaborations; Color; Communities; Data; Detection; Devices; Diagnosis; Disease; Disparity population; Distant; Electronics; Elements; Environmental Exposure; Environmental Monitoring; Environmental Pollution; Ethnic Origin; Exhibits; Exposure to; Gases; Generations; Goals; Health; Health Care Costs; Healthcare Systems; Height; Heterogeneity; Housing; Humidity; Incidence; Industrialization; Institutional Racism; Intuition; Lab On A Chip; Laboratories; Measurement; Measures; Minority; Monitor; Morbidity - disease rate; Motor Vehicles; Nitrogen Dioxide; Outcome; Ozone; Participant; Particulate Matter; Patients; Persons; Phase; Physicians; Pilot Projects; Policies; Pollution; Population; Populations at Risk; Poverty; Public Health Schools; Race; Racial Segregation; Reaction Time; Reporting; Reproducibility; Research; Research Project Grants; Resistance; Respiratory Disease; Risk; Self Care; Self Management; Semiconductors; Signal Transduction; Site; Socioeconomic Status; Source; Spatial Distribution; Spirometry; Surface; Symptoms; Temperature; Testing; Time; Transportation; United States; Universities; Wrist; airway inflammation; asthma exacerbation; asthmatic patient; battery life; cohort; conditioning; connected health; cost; design; electronic sensor; empowerment; environmental monitoring device; fine particles; health disparity; improved; indexing; innovation; integrated circuit; metal oxide; metropolitan; microsensor; miniaturized sensor; mortality; patient home care; personal exposure monitor; pollutant; portability; power consumption; prototype; psychosocial stressors; pulmonary function; recruit; residential segregation; respiratory health; response; sensor; sensor technology; sex; signal processing; smartphone application; socioeconomics; volatile organic compound; wearable device; wearable sensor technology; wireless

Project Abstract Asthma affects 25 million Americans, and chronic obstructive pulmonary disease (COPD) affects 16 million, together costing 130 billion USD annually to the US healthcare system. Asthma is more prevalent in African American population (10.6%) than white population (7.7%). Poverty level has an impact as well, with twice as much asthma incidence in people below 100% of the poverty threshold as compared to people above 450% of the threshold. Racial-ethnic and socioeconomic health disparities in the US due to air pollution exposure are well documented and have persisted despite overall decreases in ozone and particulate matter pollution. This disproportionate exposure reflects generations of discriminatory practices including racially-segregated residential policies that result in communities of color being more frequently located near major sources of air pollution, both industrial and transportation-related. The proposed research project seeks to address health disparities related to air pollution by enabling self-monitoring of environmental triggers of asthma and other respiratory diseases, so that the patients are empowered for self-management of their disease. This study will develop and test a wearable sensor array with a small form-factor for monitoring personal exposure to several important air pollutants, and then pilot this device in a small panel of African-American adults with physiciandiagnosed asthma. The device will be sensitive to a variety of primary and secondary pollutants from both motorvehicle traffic and industrial emissions. It will employ metal oxide semiconductor sensors to measure ozone, nitrogen dioxide, and volatile organic compounds as well as relative humidity and ambient temperature. The device will be able to connect to Bluetooth-enabled smartphones for data logging and display purposes, yet it will be small enough to be worn on the wrist. We will validate the utility of this device for improving health by recruiting 20 African-American adults who live in the Atlanta area and have been diagnosed with asthma. These participants will use the device to monitor their air pollution exposure for one month. During this month, they will also measure their lung function twice per day using a small commercially-available spirometer that we will provide them. We will develop a smartphone application that will clearly display air quality data in an intuitive color-coded display. The app will also include lung function data from spirometry in a percent-predicted score relative to expected values based on age, height, sex and race. The overall goal of this project is to demonstrate the feasibility of a wearable device to assist in the identification of air pollution-related asthma triggers and to empower asthma patients to improve their health by reducing exposure.

项目摘要 哮喘影响着2500万美国人，慢性阻塞性肺疾病（COPD）影响着1600万人， 每年给美国医疗系统造成1300亿美元的损失。哮喘在非洲更普遍 美国人口（10.6%）多于白色人口（7.7%）。贫困程度也有影响， 哮喘发病率在低于100%贫困线的人群中比在高于450%贫困线的人群中高得多。 门槛。在美国，由于空气污染暴露而造成的种族-民族和社会经济健康差异 尽管臭氧和颗粒物污染总体上有所减少，但这种情况仍持续存在。这 不成比例的曝光反映了几代人的歧视性做法， 导致有色人种社区更经常位于主要空气来源附近的居住政策 污染，包括工业污染和交通污染。拟议的研究项目旨在解决健康问题 通过自我监测哮喘和其他疾病的环境触发因素， 呼吸系统疾病，使病人有能力自我管理他们的疾病。本研究将 开发和测试一个可穿戴的传感器阵列与一个小的形式因素，监测个人暴露于几个 重要的空气污染物，然后在一小群非洲裔美国成年人中试用该设备，诊断为哮喘。该装置将对各种一次和二次污染物敏感，交通和工业排放。它将采用金属氧化物半导体传感器来测量臭氧， 二氧化氮和挥发性有机化合物以及相对湿度和环境温度。的 设备将能够连接到蓝牙功能的智能手机的数据记录和显示的目的，但它 将小到可以戴在手腕上。我们将通过以下方式验证该设备在改善健康方面的实用性： 招募了20名居住在亚特兰大地区并被诊断患有哮喘的非洲裔美国成年人。这些 参加者会使用仪器监测他们一个月的空气污染情况。本月，他们将 我们还使用小型商用肺活量计每天测量他们的肺功能两次， 提供它们。我们将开发一款智能手机应用程序，以直观的方式清晰显示空气质量数据。 彩色编码显示。该应用程序还将包括肺功能数据从肺功能测定在预测得分 相对于基于年龄、身高、性别和种族的预期值。本项目的总体目标是展示 可穿戴设备帮助识别与空气污染相关的哮喘触发因素的可行性， 使哮喘患者能够通过减少暴露来改善他们的健康。