Characterisation of novel mitochondrial sheet formation in yeast

酵母中新型线粒体片层形成的表征

• 批准号: 21K15083
• 负责人: May Alexander
• 金额: $ 3万
• 依托单位: Tokyo Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K15083/
• 关键词: Mitochondria; Membrane dynamics; Respiration; Cell structure

Over the previous 12 months, I have made further progress into determining the ultrastructural properties of mitochondrial membrane sheets, utilising methods including electron tomography, cryo-electron microscopy and fluorescence microscopy. With colleagues, I have also made progress in modelling the dynamics of mitochondrial sheet formation. Together, this has brought the project to an advanced stage, and I am currently preparing the results of my research for publication.I have also collaborated with colleagues on several additional papers related to this research question which have either been accepted as papers, or are currently in the review process. I plan to continue to build on this research over the coming year.

在过去的12个月里，我在确定线粒体膜片的超微结构特性方面取得了进一步的进展，使用的方法包括电子断层扫描、冷冻电子显微镜和荧光显微镜。与同事们一起，我也在线粒体薄片形成动力学建模方面取得了进展。总之，这使这个项目进入了一个高级阶段，我目前正在准备发表我的研究结果。我还与同事合作了另外几篇与这个研究问题相关的论文，这些论文要么已经被接受为论文，要么正在审稿过程中。我计划在接下来的一年里继续开展这项研究。

项目成果

Intracellular wetting mediates contacts between liquid compartments and membrane-bound organelles.

• DOI: 10.1083/jcb.202103175
• 发表时间: 2021-10-04
• 期刊: The Journal of cell biology
• 作者: Kusumaatmaja H;May AI;Knorr RL
• 通讯作者: Knorr RL

Humbolt University/MPI for Dynamics and Self-Organization(ドイツ)

洪堡大学/MPI 动力学与自组织（德国）

Humbolt University(ドイツ)

洪堡大学（德国）

Wetting of phase-separated droplets on plant vacuole membranes leads to a competition between tonoplast budding and nanotube formation.

• DOI: 10.1073/pnas.2024109118
• 发表时间: 2021-09-07
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Kusumaatmaja H;May AI;Feeney M;McKenna JF;Mizushima N;Frigerio L;Knorr RL
• 通讯作者: Knorr RL

Oslo University Hospital(ノルウェー)

奥斯陆大学医院（挪威）