Breast cancer tumors in deep tissue imaging with bi-modal NIR/MRI probe

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In this fiscal year, the developed bimodal magnetic resonance imaging (MRI)/ and near-infrared fluorescence probe conjugating to Herceptin (~ 40 nm) for HER2 breast cancer targeting. The probe composed of PLGA-b-PEG micelles encapsulating IR-1061 in the core and gadolinium-tetraazacyclododecanetetraacetic acid (Gd-DOTA) conjugated at the border of PLGA/PEG. Herceptin was then conjugated through their amine residues via EDC/NHS chemistry. The study aims to assess the performance of the designed bimodal imaging probe for detecting of breast cancers and determine the optimal conditions in vitro in order to assess the detection limit of the probe, we evaluated the specific binding activities of probe concentrations.