Contribution of cellular stress to RNA virus PAMP recognition (A12)

细胞应激对 RNA 病毒 PAMP 识别的贡献 (A12)

• 批准号: 404448943
• 金额: --
• 依托单位: Genzentrum - Laboratorium für molekulare Biologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/404448943?language=en
• 关键词: Contribution; cellular; stress; RNA; virus

This project addresses the fundamental question how persistent RNA viruses can go unrecognized by the innate immune system. The analysis of isogenic persistent and acute rabies rhabdoviruses provided experimental evidence for contribution of cellular stress sensors to virus PAMP recognition and induction of an antiviral response. Upon determination of the stress types involved it will be determined whether stress can prime RLR sensors for better recognition of viral RNA, or whether endogenous danger signals (DAMPs) are produced that synergize with viral RNA in cell activation.

该项目解决了持久性RNA病毒如何被先天免疫系统识别的基本问题。等基因持久性和急性狂犬病弹状病毒的分析提供了实验证据的贡献，细胞应激传感器的病毒PAMP识别和诱导的抗病毒反应。在确定所涉及的应激类型后，将确定应激是否可以引发RLR传感器以更好地识别病毒RNA，或者是否产生在细胞活化中与病毒RNA协同作用的内源性危险信号（DAMP）。