Defining predictors of anti-viral immunity in the yellow fever vaccination model using gene polymorphisms and early innate response patterns (B14)

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Cooperation of multiple nucleic acid sensors and antigen presenting cell (APC) subpopulations is thought to be critical for generating effective and long-lasting adaptive immunity to infection and vaccination. We use the live-attenuated yellow fever virus (YF17D) vaccination as a model of an acute self-limiting RNA virus infection in humans. We will apply (expression) quantitative trait loci (eQTL) analysis and single cell transciptome and epigenome analysis of circulating innate immune cells before and after YF17D vaccination. Thereby we will identify new factors that regulate nucleic acid sensing pathways and decipher the genetic basis of inter-individual variability in antiviral immunity.