Dissecting and exploiting radiation-imposed reprogramming and metastasis in PDAC (P15)

剖析和利用 PDAC 中辐射引起的重编程和转移 (P15)

• 批准号: 404502126
• 金额: --
• 依托单位: Klinik und Poliklinik für Radioonkologie und Strahlentherapie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/404502126?language=en
• 关键词: Dissecting; exploiting; radiation; imposed; reprogramming

Next to tumor cell-intrinsic factors, extrinsic factors play a role in radioresistance, tumor relapse and metastasis. Therefore, we will determine the influence of the tumor microenvironment on the radioresistance and investigate tumor relapse and metastasis after radiation therapy in different PDAC mouse models. Therapeutic targets will be identified and targeted by genetic and pharmacological approaches in combination with radiotherapy. These targeted therapy concepts should provide the basis for novel multimodal clinical treatment approaches.

除肿瘤细胞内源性因素外，外源性因素在肿瘤的放射抵抗、复发和转移中也起重要作用。因此，我们将确定肿瘤微环境对放射抗性的影响，并在不同的PDAC小鼠模型中研究放射治疗后的肿瘤复发和转移。将通过遗传学和药理学方法结合放射治疗来确定和靶向治疗靶点。这些靶向治疗的概念应提供新的多模式临床治疗方法的基础。