Temperature-driven regulation system of hypermucoviscosity in carbapenem-resistant Klebsiella pneumoniae

耐碳青霉烯类肺炎克雷伯菌高粘膜粘度的温度驱动调节系统

• 批准号: 21K16947
• 负责人: LE NGUYEN・TRA・MI
• 金额: $ 3万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K16947/
• 关键词: Klebsiella pneumoniae; hypervirulent; multidrug resistance; antimicrobial peptide; bacteriocin; hypermucoviscous; string test; antimicrobial resistance; hypervirulence; hypemucoviscosity

Multidrug-resistant and hypervirulent K. pneumoniae has been continuously evolving, which causes severe clinical outcome and significantly challenges the available chemotherapeutic treatment for its infections.K. pneumoniae produces several kinds of antimicrobial peptides known as bacteriocins, which have antibacterial activity against closely-related species. Bacteriocins are considered one of K. pneumoniae virulence factors. We identified bacteriocin genes in 180 K. pneumoniae species complex genomes, including 170 hypermucoviscous isolates, and investigated the antibacterial activity against 50 strains, including antimicrobial-resistant organisms, belonging to multiple species. This study has been accepted on April 11th and published on May 8th in Microbiology Spectrum:Le MN, Nguyen TH, Trinh VM, Nguyen TP, Kawada-Matsuo M, Kayama S, Sugai M, Komatsuzawa H. Comprehensive Analysis of Bacteriocins Produced by the Hypermucoviscous Klebsiella pneumoniae Species Complex. Microbiol Spectr. 2023 May 8:e0086323. doi: 10.1128/spectrum.00863-23. Epub ahead of print. PMID: 37154746.

多重耐药性和高毒力肺炎克雷伯菌一直在不断进化，导致严重的临床结果，并对现有的感染化疗方法提出了重大挑战。肺炎杆菌产生多种被称为细菌素的抗菌肽，它们对密切相关的物种具有抗菌活性。细菌素被认为是肺炎克雷伯菌毒力因子之一。我们在 180 个肺炎杆菌复杂基因组（包括 170 个高粘膜分离株）中鉴定了细菌素基因，并研究了对 50 个菌株的抗菌活性，包括属于多个物种的耐药微生物。该研究已于 4 月 11 日被接受，并于 5 月 8 日发表在 Microbiology Spectrum 上：Le MN, Nguyen TH, Trinh VM, Nguyen TP, Kawada-Matsuo M, Kayama S, Sugai M, Komatsuzawa H. 超粘粘性肺炎克雷伯氏菌复合体产生的细菌素的综合分析。微生物光谱。 2023 年 5 月 8 日：e0086323。 doi：10.1128/spectrum.00863-23。电子版先于印刷版。 PMID：37154746。

项目成果

ORCID

• DOI: 10.5195/jmla.2017.89
• 发表时间: 2017-04
• 期刊: Journal of the Medical Library Association : JMLA
• 作者: Evan Sprague

Monash University(オーストリア)

莫纳什大学（奥地利）

London School(英国)

伦敦学校（英国）

Department of Infectious Diseases/Monash University(オーストラリア)

传染病系/莫纳什大学（澳大利亚）

Comprehensive analysis of bacteriocins produced by Klebsiella pneumoniae complex

肺炎克雷伯菌复合体产生的细菌素的综合分析

• 发表时间: 2023
• 作者: Le Mi Nguyen-Tra;Kayama Shizuo;Wyres Kelly L.;Yu Liansheng;Hisatsune Junzo;Suzuki Masato;Yahara Koji;Terachi Tsuneko;Sawa Kana;Takahashi Shin;Okuhara Toshihiko;Kohama Kunihiko;Holt Kathryn E.;Mizutani Tetsu;Ohge Hiroki;Sugai Motoyuki;Mi Nguyen-Tra Le
• 通讯作者: Mi Nguyen-Tra Le