Aberrant Cathepsin S (CTSS) Activity in Follicular Lymphoma (P04)

点击翻译按钮获取中文摘要

We discovered a clinically relevant mechanism of tumour and immune cell interaction in follicular lymphoma, a prototypical type of blood cancer. Cathepsin S (CTSS) alterations result in aberrant hyperactivity of this lysosomal cysteine protease and induce a tumour-promoting CD4 T cell enriched immune microenvironment. We use innovative ex vivo and in vivo models to functionally define and therapeutically target these tumour-promoting interactions. Furthermore, we identified intriguing roles of CTSS in NF-κB and TLR signalling, and -unexpectedly- in the nucleus. Defining and targeting the unique pathobiology of CTSS hyperactive tumours is expected to provide a strong rationale for its translation into the clinic.