From non-ribosomal peptide synthesis to translation (P10)

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The origin of translation continues to be one of the most difficult problems of prebiotic evolution. There must have been a simpler form of RNA-induced peptide synthesis that then evolved into the ever more sophisticated system of modern biology. We have already established the first ribosome-free form of translation, where, depending on the RNA template, different amino acids are incorporated at the C-terminus of a growing peptido RNA in the absence of enzymes. We aim to extend this form of translation to longer sequences by improving spatial control over template, primer and tRNA species.