From non-ribosomal peptide synthesis to translation (P10)

翻译的起源仍然是生命前进化中最困难的问题之一。一定有一种更简单的形式的RNA诱导的多肽合成，然后进化成了越来越复杂的现代生物学系统。我们已经建立了第一种无核糖体的翻译形式，根据RNA模板的不同，不同的氨基酸在没有酶的情况下被结合在生长中的多肽RNA的C末端。我们的目标是通过改善对模板、引物和tRNA物种的空间控制，将这种形式的翻译扩展到更长的序列。

The origin of translation continues to be one of the most difficult problems of prebiotic evolution. There must have been a simpler form of RNA-induced peptide synthesis that then evolved into the ever more sophisticated system of modern biology. We have already established the first ribosome-free form of translation, where, depending on the RNA template, different amino acids are incorporated at the C-terminus of a growing peptido RNA in the absence of enzymes. We aim to extend this form of translation to longer sequences by improving spatial control over template, primer and tRNA species.