Investigating the influence of two major Ionotropic Receptors on Aedes aegypti mosquito acoustic behaviors

研究两种主要离子型受体对埃及伊蚊声学行为的影响

• 批准号: 22K15159
• 负责人: SU Matthew
• 金额: $ 2.91万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K15159/
• 关键词: Aedes mosquitoes; Hearing; Thermosensation; Ionotropic receptors; Mosquito; Ionotropic Receptors

I have successfully generated an IR21a homozygous negative mutant and investigated the influence of temperature on male mutant hearing systems. No significant changes in hearing sensitivity have been found, though this mutant appears to demonstrate altered humidity sensation rather than thermosensation. Interestingly, the distribution of IR21a in Aedes mosquitoes appear distinct from other mosquito species, potentially suggesting changes in function.I am currently generating an Ir25a homozygous negative mutant so that I can also perform assays on this line. I am also expanding my research into other Ionotropic Receptors which I have identified in ear tissues to investigate their potential role in hearing thermosensitivity.

我已经成功地产生了一个IR21a纯合负突变体，并研究了温度对男性突变听力系统的影响。没有发现听觉灵敏度的显着变化，尽管这种突变体似乎表现出改变的湿度感觉，而不是温度感觉。有趣的是，IR21a在伊蚊中的分布似乎与其他蚊子物种不同，可能表明功能的变化。我目前正在产生一个IR25a纯合阴性突变体，以便我也可以在这条线上进行检测。我也正在扩展我的研究到其他离子型受体，我已经确定在耳组织中，以调查他们在听力热敏性的潜在作用。

项目成果

Comparing hearing function and behaviors in Aedes aegypti and Aedes albopictus mosquitoes

比较埃及伊蚊和白纹伊蚊的听力功能和行为

• 发表时间: 2022
• 作者: Xu Yifeng Y. J.;Loh YuMin M.;Lee Tai-Ting;Ohashi Takuro S.;Su Matthew P.;Kamikouchi Azusa;Su Matthew Paul;Su Matthew Paul;Su Matthew Paul
• 通讯作者: Su Matthew Paul

Sexual dimorphisms in Aedes mosquito hearing function and behavior

伊蚊听觉功能和行为的性别二态性

• 发表时间: 2023
• 作者: Xu Yifeng Y. J.;Loh YuMin M.;Lee Tai-Ting;Ohashi Takuro S.;Su Matthew P.;Kamikouchi Azusa;Su Matthew Paul
• 通讯作者: Su Matthew Paul

Investigating the underlying connections between mosquito hearing, courtship and the circadian clock

研究蚊子听觉、求偶和生物钟之间的潜在联系

• 发表时间: 2022
• 作者: Xu Yifeng Y. J.;Loh YuMin M.;Lee Tai-Ting;Ohashi Takuro S.;Su Matthew P.;Kamikouchi Azusa;Su Matthew Paul;Su Matthew Paul
• 通讯作者: Su Matthew Paul