Elucidating the role of Arc in determining cell ensemble dynamics underlying associative learning

阐明 Arc 在确定关联学习背后的细胞整体动力学中的作用

• 批准号: 22K15199
• 负责人: BREBNER LEONIE
• 金额: $ 2.91万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K15199/
• 关键词: Brain; Neuron; Calcium; Arc; Neuroscience; Learning; Ensemble

The immediate early gene Arc has previously been shown to be expressed in a small number of highly activated neurons during memory formation. Once expressed, it is involved in mediating heterosynaptic long-term depression in a select group of neurons. As such, it is thought to contribute to memory consolidation, yet the mechanisms underlying this process are not well known. Here, we used novel methods to track the activity of Arc expressing neurons across learning. We also used a novel mouse model to test the effect of localized cortical Arc knockout during learning. We find that Arc expression and neuronal activity show a bidirectional and modulatory relationship during associative learning which in turn affects memory encoding.

早期基因Arc先前已被证明在记忆形成期间在少数高度活化的神经元中表达。一旦表达，它就参与介导一组选定神经元中的异突触长期抑制。因此，它被认为有助于记忆巩固，但这一过程的机制尚不清楚。在这里，我们使用了新的方法来跟踪Arc表达神经元在学习过程中的活动。我们还使用了一种新的小鼠模型来测试学习过程中局部皮质Arc敲除的效果。我们发现，在联想学习过程中，Arc的表达和神经元的活动表现出双向和调节的关系，进而影响记忆编码。

项目成果

Deciphering Arc-dependent control of circuit dynamics underlying the consolidation of associative memories

破译基于关联记忆巩固的电路动力学的电弧相关控制

• 发表时间: 2023
• 作者: 増田亘作;渡邉綾乃;丹羽康貴;平野有沙;Masafumi Tsuboi;Brebner Leonie
• 通讯作者: Brebner Leonie