Event segmentation and the activity of CA1 engram cells in segregated environments

事件分割和隔离环境中 CA1 印迹细胞的活动

• 批准号: 22K15236
• 负责人: 王 家暄
• 金额: $ 2.25万
• 依托单位: Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K15236/
• 关键词: CA1; place cells; engram cells; spatial segregation; boundary; hippocampus; physiology; place cell; engram cell; memory

In order to understand how spatial segregation affects our perception and memory about a space, electrophysiological signal was collected from the hippocampal area of mouse when the animal was navigating open platforms with different floor textures. On the "segregated" platform, a speed bump-like protrusion on the floor segregated the platform into two halves; while on the "non-segregated" platform, a protrusion with identical length and width existed but did not segregate the platform.In the past year, I built hyperdrives equipped with multiple individually-adjustable tetrodes and successfully collected CA1 multiunit signals from 5 mice. The data are to be preprocessed and analyzed.

为了了解空间隔离是如何影响我们对一个空间的感知和记忆的，我们从小鼠的海马区采集了电生理信号，当动物在不同地板纹理的开放平台上航行时。在“隔离”平台上，地板上一个减速带状的突起将平台分成两半；而在“非隔离”平台上，存在一个长度和宽度相同的突起，但没有分隔平台。在过去的一年里，我建造了配备多个单独可调四极管的超驱动器，并成功采集了5只小鼠的CA1多单位信号。对采集到的数据进行预处理和分析。