The Pathophysiological Factors Driving Diastolic Dysfunction of the Right Heart in Pulmonary Hypertension
The Pathophysiological Factors Driving Diastolic Dysfunction of the Right Heart in Pulmonary Hypertension
肺动脉高压右心舒张功能障碍的病理生理因素
批准号：
22K15368
负责人：
Waddingham Mark
金额：
$2.91万
依托单位国家：
日本
项目类别：
Grant-in-Aid for Early-Career Scientists
财政年份：
2022
资助国家：
日本
项目状态：
未结题
起止时间：
2022-04-01 至 2025-03-31
中文摘要
翻译
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英文摘要
In the first year of this proposal, I have begun developing the model of Group 2 pulmonary hypertension, using the Dahl-Iwai salt-sensitive (DIS) rat combined with a 4% NaCl diet for 12 weeks. So far we have established that when compared to the salt-resistant (DIR) control rats, DIS rats tend to develop left ventricular hypertrophy and demonstrate evidence of early diastolic dysfunction. Right ventricle (RV) catheterisation has revealed that DIS rats have slightly elevated pulmonary pressures, in particular during cardiac fluid challenge testing. Further analysis of RV diastolic function is function is currently being undertaken.
期刊论文(6)
专著(0)
科研奖励(0)
会议论文
The Super Relaxed State of Myosin Contributes to the Pathogenesis of Right Ventricular Dysfunction in Pulmonary Hypertension
肌球蛋白的超松弛状态导致肺动脉高压右心室功能障碍的发病机制
肌球蛋白的超松弛状态导致肺动脉高压右心室功能障碍的发病机制
DOI：
--
发表时间：
2022
期刊：
影响因子：
--
作者：
[Waddingham MT, Tsuchimochi H, Asano R, Sonobe T, Higuchi T, Aoyama K, Shirai M, Pearson JT, Ogo T]
通讯作者：
Ogo T
Myofilament protein post-translational modifications may underlie right ventricular dysfunction in pulmonary hypertension
肌丝蛋白翻译后修饰可能是肺动脉高压右心室功能障碍的基础
肌丝蛋白翻译后修饰可能是肺动脉高压右心室功能障碍的基础
DOI：
--
发表时间：
2023
期刊：
影响因子：
--
作者：
[Waddingham MT, Tsuchimochi H, Ogo T, Pearson JT]
通讯作者：
Pearson JT
海外基金
