The Pathophysiological Factors Driving Diastolic Dysfunction of the Right Heart in Pulmonary Hypertension

肺动脉高压右心舒张功能障碍的病理生理因素

• 批准号: 22K15368
• 负责人: Waddingham Mark
• 金额: $ 2.91万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K15368/
• 关键词: Pulmonary Hypertension; Right Ventricle; Myocardium; Diastolic Dysfunction; Sarcomere; Microtubules; Heat Shock Proteins; Cardiomyocyte

In the first year of this proposal, I have begun developing the model of Group 2 pulmonary hypertension, using the Dahl-Iwai salt-sensitive (DIS) rat combined with a 4% NaCl diet for 12 weeks. So far we have established that when compared to the salt-resistant (DIR) control rats, DIS rats tend to develop left ventricular hypertrophy and demonstrate evidence of early diastolic dysfunction. Right ventricle (RV) catheterisation has revealed that DIS rats have slightly elevated pulmonary pressures, in particular during cardiac fluid challenge testing. Further analysis of RV diastolic function is function is currently being undertaken.

在这个提议的第一年，我已经开始开发第2组肺动脉高压的模型，使用Dahl-Iwai盐敏感（DIS）大鼠结合4%NaCl饮食12周。到目前为止，我们已经确定，与耐盐（DIR）对照大鼠相比，DIS大鼠往往会出现左心室肥大，并表现出早期舒张功能障碍的证据。右心室（RV）导管插入术显示，DIS大鼠的肺压略有升高，特别是在心脏液体挑战试验期间。目前正在对RV舒张功能进行进一步分析。

项目成果

The Super Relaxed State of Myosin Contributes to the Pathogenesis of Right Ventricular Dysfunction in Pulmonary Hypertension

肌球蛋白的超松弛状态导致肺动脉高压右心室功能障碍的发病机制

• 发表时间: 2022
• 作者: Waddingham MT;Tsuchimochi H;Asano R;Sonobe T;Higuchi T;Aoyama K;Shirai M;Pearson JT;Ogo T
• 通讯作者: Ogo T

Myofilament protein post-translational modifications may underlie right ventricular dysfunction in pulmonary hypertension

肌丝蛋白翻译后修饰可能是肺动脉高压右心室功能障碍的基础

• 发表时间: 2023
• 作者: Waddingham MT;Tsuchimochi H;Ogo T;Pearson JT
• 通讯作者: Pearson JT