Multifunctional liposomal containers based on polymeric microgels

该项目旨在设计和开发由脂多糖微凝胶、双层脂囊(脂质体)和线性多糖组成的可生物降解的纳米结合物。(1)阳离子线性聚合物和阴离子脂质体，或(2)阳离子脂质体和阴离子线性聚合物，在阴离子微凝胶颗粒表面的连续静电吸附将导致形成表面带负电荷的多脂质体载体(纳米结合物)，从而提高生物环境中的抗聚集稳定性。脂质体和微凝胶都将被用来包裹生物活性物质，这将允许增加纳米结合物的有用容量，并制备具有受控包埋物含量的纳米结合物。

The project aims to design and develop biodegradable nanoconjugates consisting of apolysaccharide microgel, bilayer lipid vesicles (liposomes) and a linear polysaccharide.Consecutive electrostatic adsorption of (1) a cationic linear polymer and anionic liposomes, or (2)cationic liposomes and an anionic linear polymer, on the surface of anionic microgel particles will result in formation of multiliposomal carriers (nanoconjugates) with negative surface charge and increased stability against aggregation in biological environment. Both liposomes and microgels will be used to encapsulate biologically active substances that will allow increasing the useful capacity of the nanoconjugates and preparing the nanoconjugates with the controlled content of encapsulated substances.