Advanced Functional Carriers Based on Polyelectrolyte-Liposome Complexes

该项目旨在开发功能性多脂质体构建体以及研究其结构和性质。用于制造多脂质体构建体的策略是基于使用阳离子聚合物颗粒作为脂质体载体，其具有与阴离子脂质体静电相互作用的复杂结构。作为阳离子聚合物颗粒，我们打算使用富含来自其聚合物组分之一的离子基团的星形同臂或杂臂离子聚合物或插入络合物聚合物囊泡。阳离子聚合物颗粒与阴离子脂质体的共组装体的结构和性质将通过各种实验技术的组合来检查，包括基于荧光、散射和分析超离心的方法。这种复杂的构建体是相当感兴趣的，因为它们用于（冲突的）药物和活性化合物的组合递送的潜在应用，期望协同效应。

The proposed project aims at the development of functional multiliposomal constructs as well as the investigation of their structure and properties. The strategy for the fabrication of the multiliposomal constructs is based on the use of cationic polymer particles as liposome carriers with complex architectures interacting electrostatically with anionic liposomes. As cationic polymer particles, we intend to use star-shaped homo- or heteroarm ionic polymers or interpolyelectrolyte complex polymersomes enriched with ionic groups from one of their polymeric components. The structure and properties of the co-assemblies of the cationic polymer particles with the anionic liposomes will be examined by a combination of various experimental techniques including methods based on fluorescence, scattering and analytical ultracentrifugation. Such complex constructs are of considerable interest because of their potential application for a combined delivery of (conflicting) drugs and active compounds, expecting synergistic effects.