Advanced Functional Carriers Based on Polyelectrolyte-Liposome Complexes

基于聚电解质-脂质体复合物的先进功能载体

• 批准号: 259595799
• 负责人: Professor Dr. Walter Richtering
• 金额: --
• 依托单位: Lehrstuhl für Physikalische Chemie II
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/259595799?language=en
• 关键词: Advanced; Functional; Carriers; Based; Polyelectrolyte

The proposed project aims at the development of functional multiliposomal constructs as well as the investigation of their structure and properties. The strategy for the fabrication of the multiliposomal constructs is based on the use of cationic polymer particles as liposome carriers with complex architectures interacting electrostatically with anionic liposomes. As cationic polymer particles, we intend to use star-shaped homo- or heteroarm ionic polymers or interpolyelectrolyte complex polymersomes enriched with ionic groups from one of their polymeric components. The structure and properties of the co-assemblies of the cationic polymer particles with the anionic liposomes will be examined by a combination of various experimental techniques including methods based on fluorescence, scattering and analytical ultracentrifugation. Such complex constructs are of considerable interest because of their potential application for a combined delivery of (conflicting) drugs and active compounds, expecting synergistic effects.

该项目旨在开发功能性多脂质体构建体以及研究其结构和性质。用于制造多脂质体构建体的策略是基于使用阳离子聚合物颗粒作为脂质体载体，其具有与阴离子脂质体静电相互作用的复杂结构。作为阳离子聚合物颗粒，我们打算使用富含来自其聚合物组分之一的离子基团的星形同臂或杂臂离子聚合物或插入络合物聚合物囊泡。阳离子聚合物颗粒与阴离子脂质体的共组装体的结构和性质将通过各种实验技术的组合来检查，包括基于荧光、散射和分析超离心的方法。这种复杂的构建体是相当感兴趣的，因为它们用于（冲突的）药物和活性化合物的组合递送的潜在应用，期望协同效应。

项目成果

Complexes of star-shaped cationic polyelectrolytes with anionic liposomes: Towards multi-liposomal assemblies with controllable stability

• DOI: 10.1016/j.polymer.2016.04.025
• 发表时间: 2016-06
• 期刊: Polymer
• 影响因子: 4.6
• 作者: A. Sybachin;O. V. Zaborova;D. Pergushov;A. Zezin;F. Plamper;A. Müller;E. Kesselman;Judith Schmidt;Y. Talmon;F. Menger;A. Yaroslavov

Effects of the electrostatic complexation between anionic pH-sensitive liposomes and star-shaped polycations on the release of the liposomal content

阴离子pH敏感脂质体与星形聚阳离子之间的静电络合对脂质体内容物释放的影响

• DOI: 10.1016/j.mencom.2016.07.002
• 发表时间: 2016
• 期刊: Mendeleev Communications
• 影响因子: 1.9
• 作者: A. V. Sybachin;O. V. Zaborova;K. M. Imelbaeva;V. V. Samoshin;V. A. Migulin;F. A. Plamper;A. A. Yaroslavov
• 通讯作者: A. A. Yaroslavov

Adjusting the size of multicompartmental containers made of anionic liposomes and polycations by introducing branching and PEO moieties

通过引入支化和 PEO 部分来调整由阴离子脂质体和聚阳离子制成的多室容器的尺寸

• DOI: 10.1016/j.polymer.2017.05.041
• 发表时间: 2017
• 期刊: Polymer
• 影响因子: 4.6
• 作者: C. E. Pinguet;J. M. Hoffmann;A. A. Steinschulte;A. Sybachin;K. Rahimi;D. Wöll;A. Yaroslavov;W. Richtering;F. A. Plamper
• 通讯作者: F. A. Plamper

Payload release by liposome burst: Thermal collapse of microgels induces satellite destruction.

脂质体爆裂释放有效载荷：微凝胶的热塌陷导致卫星破坏

• DOI: 10.1016/j.nano.2017.02.001
• 发表时间: 2017
• 期刊: Nanomedicine : nanotechnology, biology, and medicine
• 作者: A. Yaroslavov;I. Panova;A. Sybachin;V. Spiridonov;A. Zezin;O. Mergel;A. Gelissen;R. Tiwari;F. Plamper;W. Richtering;F. Menger
• 通讯作者: F. Menger

PEO-b-PPO star-shaped polymers enhance the structural stability of electrostatically coupled liposome/polyelectrolyte complexes

PEO-b-PPO星形聚合物增强静电耦合脂质体/聚电解质复合物的结构稳定性

• DOI: 10.1371/journal.pone.0210898
• 发表时间: 2019
• 期刊: PLoS ONE
• 影响因子: 3.7
• 作者: C. E. Pinguet;E. Ryll;A. A. Steinschulte;J. M. Hoffmann;M. Brugnoni;A. Sybachin;D. Wöll;A. Yaroslavov;W. Richtering;F. A. Plamper
• 通讯作者: F. A. Plamper