Advanced Functional Carriers Based on Polyelectrolyte-Liposome Complexes

该项目旨在开发功能性多脂质体，并对其结构和性质进行研究。多脂质体的制备策略是基于阳离子聚合物颗粒作为具有复杂结构的脂质体载体与阴离子脂质体静电相互作用的基础上。作为阳离子聚合物粒子，我们打算使用星形的同臂或杂臂离子聚合物或聚电解质间络合物聚合物，这些聚合物中的一个聚合成分含有丰富的离子基团。阳离子聚合物粒子与阴离子脂质体共组装的结构和性质将通过各种实验技术的组合进行检测，包括基于荧光、散射和分析超速离心法的方法。这种复杂的结构具有相当大的吸引力，因为它们可能应用于(相互冲突的)药物和活性化合物的组合输送，期望产生协同效应。

The proposed project aims at the development of functional multiliposomal constructs as well as the investigation of their structure and properties. The strategy for the fabrication of the multiliposomal constructs is based on the use of cationic polymer particles as liposome carriers with complex architectures interacting electrostatically with anionic liposomes. As cationic polymer particles, we intend to use star-shaped homo- or heteroarm ionic polymers or interpolyelectrolyte complex polymersomes enriched with ionic groups from one of their polymeric components. The structure and properties of the co-assemblies of the cationic polymer particles with the anionic liposomes will be examined by a combination of various experimental techniques including methods based on fluorescence, scattering and analytical ultracentrifugation. Such complex constructs are of considerable interest because of their potential application for a combined delivery of (conflicting) drugs and active compounds, expecting synergistic effects.