心不全患者で生じる筋力制御不全の病態解明と心臓リハビリテーションの効果検証

阐明心力衰竭患者肌肉失调的病理并验证心脏康复的效果

• 批准号: 22K17646
• 负责人: 梅原 拓也
• 金额: $ 3万
• 依托单位: Hiroshima International University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K17646/
• 关键词: 心不全; 最大下筋力; 制御不良; 多チャンネル表面筋電図; 心不全患者; 筋力制御不全; 心臓リハビリテーション

本研究の目的の1つとしては、心不全患者が健常高齢者より最大下筋力の制御不良が生じているかどうかを定量的に評価することであった。対象者は、健常高齢者と入院治療を要した心不全患者とした。健常高齢者は、疾患を有していないかつ心不全患者と同年代とした。対象者は、歩行が可能で日常生活動作が自立している者を対象とした。ハンドヘルドダイナモメーターを用いて等尺性膝関節伸展筋力の最大随意筋力（MVC）を測定した。要求する運動課題は、20%、40%、60%のMVCでの台形課題を行わせた。台形課題における対象者が行った運動課題との差異を算出した（数値が大きくなるほど要求した運動課題から離れている）。測定時期は、健常高齢者が高齢者サロンに参加時、心不全患者が退院時とした。統計解析は、運動課題要因と群間要因（心不全と健常高齢者）で二元配置分散分析を行った。運動課題の差異は、20%課題で心不全患者が3.7±2.3、健常高齢者が2.3±1.1、40%課題で心不全患者が4.2±2.9、健常高齢者が3.7±2.2、60%課題で心不全患者が4.1±2.0、健常高齢者が5.5±2.1であった。二元配置分散分析の結果、運動課題要因と群間要因で有意な主効果がなかった。ただ、本研究は、心不全患者と健常高齢者の対象者が予定人数より少ないため、引き続き、測定を行う。そして、心不全患者は、健常高齢者より骨格筋量、筋力や筋質低下があり、これらと多チャンネル表面筋電図を含めて最大下筋力の制御不良の関連を明らかにしていく。

The purpose of this study was to determine the maximum lower muscle strength of patients with cardiac insufficiency and patients with cardiac insufficiency. The elephant, the healthy and high altitude sickness should be admitted to the hospital to treat the patients with cardiac insufficiency. The patients with normal and high levels of diabetes, the patients with heart failure, the patients with heart failure, the patients with heart failure and the patients with cardiac insufficiency. "Elephant", "Xing" may be "self-reliant" and "self-reliant" in daily life. The maximum random tendon strength (MVC) is measured by using the same scale knee stretch strength (maximum random strength). It is required that 20%, 40% and 60% of MVC projects should be completed. The person who is responsible for the simulation of the Taiwan problem is responsible for the calculation of the error of the problem (a large number of people are required to do so). When the patients with heart failure were discharged from the hospital, the patients with heart failure were not allowed to leave the hospital during the test period, the patients with normal hypertension and the patients with heart failure. Statistical analysis of behavior problems is due to the decentralized analysis of binary configuration among groups (those with incomplete heart disease and normal health). The scores of exercise deficit, 20% of patients with incomplete heart disease, those with normal high heart disease, 40% with heart insufficiency, healthy high heart disease and healthy high heart disease were 3.7 ±2.3, 3.7 ±2.2, 4.1 ±2.0, 2.3 ±1.1, 4.2 ±2.9, 3.7 ±2.2 and 5.5 ±2.1 respectively. The results of the binary configuration decentralized analysis and the action problems are due to the intentional results between the groups. In this study, the number of patients with cardiac insufficiency, those who were healthy, the patients who were healthy, the patients who were normal, the patients with cardiac insufficiency, the patients with cardiac insufficiency and the patients with cardiac insufficiency. Patients with heart failure, patients with cardiac insufficiency, patients with normal and high heart disease are required to measure the amount of bone reinforcement, the amount of muscle strength, the amount of muscle strength, and the maximum strength of the surface tendon electronic. to control poor health.