Platelet CyPA/ RAGE as modulators of inflammation and immune responses during myocardial remodelling and aneurysm formation (B03)

血小板 CyPA/RAGE 作为心肌重塑和动脉瘤形成过程中炎症和免疫反应的调节剂 (B03)

• 批准号: 406447642
• 金额: --
• 依托单位: Innere Medizin III: Kardiologie und Kreislauferkrankungen
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/406447642?language=en
• 关键词: Platelet; CyPA; RAGE; modulators; inflammation

In this project, we study the functional role of Cyclophilin A (CyPA) secreted from platelets in cardiovascular disease models. Based on prior observations that extracellular CyPA drives angiotensin II-induced cardiac hypertrophy and abdominal aortic aneurysm formation, this project will apply a novel mouse model to delete CyPA specifically in platelets for studying the role of platelet-derived CyPA in these disease models. This project will also evaluate the role of recently identified CyPA receptors in mediating CyPA effects herein. In addition, the principal function of platelet activation and degranulation in cardiac hypertrophy and aortic aneurysm formation will be studied using different genetic mouse models.

在本项目中，我们研究血小板分泌的亲环蛋白A （CyPA）在心血管疾病模型中的功能作用。基于先前的观察，细胞外CyPA驱动血管紧张素ii诱导的心脏肥大和腹主动脉瘤形成，本项目将应用一种新的小鼠模型来特异性地删除血小板中的CyPA，以研究血小板来源的CyPA在这些疾病模型中的作用。本项目还将评估最近发现的CyPA受体在介导CyPA作用中的作用。此外，血小板活化和脱颗粒在心脏肥大和主动脉瘤形成中的主要功能将通过不同的遗传小鼠模型进行研究。