The role of platelets in pulmonary inflammation during ARDS (B07)

血小板在 ARDS 期间肺部炎症中的作用 (B07)

• 批准号: 406490075
• 金额: --
• 依托单位: Klinik für Anaesthesiologie und Intensivmedizin
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/406490075?language=en
• 关键词: role; platelets; pulmonary; inflammation; during

We have shown that major platelet adhesion and activation pathways orchestrate inflammation and leukocyte recruitment to the alveolar space in the course of experimental Acute Respiratory Distress Syndrome (ARDS). Furthermore, platelets also critically contribute to the immune response during an infectious insult and they influence the extent of secondary organ injury during ARDS. The regeneration of the lung and the resolution of inflammation following inflammation or infection are also influenced by platelets. We plan to further dissect the molecular mechanisms underlying platelet-orchestrated immune processes and the regeneration of the lung during ARDS. For this, we will utilise a broad range of genetically modified mouse models, infectious models of ARDS and advanced imaging methods.

我们已经表明，在实验性急性呼吸窘迫综合征（ARDS）的过程中，主要的血小板粘附和活化途径协调炎症和白细胞募集到肺泡腔。此外，血小板还在感染性损伤期间对免疫应答起关键作用，并且它们影响ARDS期间继发器官损伤的程度。肺的再生和炎症或感染后炎症的消退也受到血小板的影响。我们计划进一步剖析血小板协调免疫过程和ARDS期间肺再生的分子机制。为此，我们将利用广泛的转基因小鼠模型、ARDS感染模型和先进的成像方法。