Role of platelets in tissue remodelling and functional recovery after experimental cerebral ischaemia (B04+)

血小板在实验性脑缺血后组织重塑和功能恢复中的作用（B04）

• 批准号: 406447995
• 金额: --
• 依托单位: Klinik für Neurologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/406447995?language=en
• 关键词: Role; platelets; tissue; remodelling; functional

In B04, we will assess whether platelets play a pathophysiological role during post-stroke recovery and late-stage tissue remodelling. The main focus will be on platelet-mediated thrombo-inflammation as well as potential extravascular effects of platelets, e.g. induction of apoptosis. Translationally meaningful mouse models, novel pharmacological inhibitors, and advanced imaging techniques will be used to investigate our research questions.

在B04，我们将评估血小板在卒中后恢复和晚期组织重塑过程中是否起到病理生理作用。主要的焦点将集中在血小板介导的血栓炎症以及血小板的潜在血管外效应，例如诱导细胞凋亡。具有翻译意义的小鼠模型、新型药理抑制剂和先进的成像技术将被用来研究我们的研究问题。