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Development of tissue blood flowmeter employing heat clearance curve, and its clinical application.

热清除率曲线组织血流量计的研制及其临床应用

基本信息

批准号：
61870112
负责人：
HANDA Kenjiro
金额：
$ 2.43万
依托单位：
Shinshu University School of MEdicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1988
项目状态：
已结题

项目摘要

1) A new heat-clearance flowmeter A new heat-clearance flowmeter was developed in order to measure tissue blood flow. The sensor was composed of copper-constantan thermocouples and a constantan heating wire wrapped around one of the two thermocouples. These configurations are placed inside two 10mm long stainless steel pipes, in diameter at 630um and 410um, respectively. An electric current through a constand current circuit was applied to the heater for a set period of time. The clearance curve was then measured.2) Animal experiment Four living sheep were used as specimen, and it was demonstrated that the clearance curve gradients and the volume of blood flow show a fairly high degree of correlation and there were no observal difference in the four specimen samples. Therefore, it seems clear that this method can be applied successfully to other animals or organs in order to measure tissue blood flow rapidly. The procedure of measurements is very convenient and aseptic insertion of the electrode makes the clinical application possible.3) Clinical application We tried to measure tissue blood flow at bronchial mucosa, using this new heat-clearance flow meter. Improvement of the sensor were required to be applied clinically.

1）新型热间隙流量计为了测量组织血流量，开发了一种新型热间隙流量计。该传感器由铜-康铜热电偶和缠绕在两个热电偶之一上的康铜加热丝组成。这些配置放置在两根 10 毫米长的不锈钢管内，直径分别为 630 微米和 410 微米。通过恒流电路的电流被施加到加热器一段设定的时间。 2)动物实验以4只活羊为标本,结果表明,4个标本的清除率曲线梯度与血流量呈现出较高的相关性,且无明显差异。因此，很明显，这种方法可以成功地应用于其他动物或器官，以快速测量组织血流量。测量过程非常方便，电极的无菌插入使临床应用成为可能。3）临床应用我们尝试使用这种新型热间隙流量计来测量支气管粘膜处的组织血流量。需要对传感器进行改进才能应用于临床。