Development of tissue blood flowmeter employing heat clearance curve, and its clinical application.

1)一种新型热隙式流量计为了测量组织血流量，研制了一种新型热隙式流量计。该传感器由铜-康铜热电偶和缠绕在其中一个热电偶上的康铜加热丝组成。这些配置被放置在两个10 mm长的不锈钢管中，直径分别为630 um和410 um。将通过恒定电流电路的电流施加到加热器持续设定的时间段。2）动物实验采用4只活体绵羊作为标本，证明了清除曲线梯度与血流量具有较高的相关性，且4种标本之间无明显差异。因此，很明显，这种方法可以成功地应用于其他动物或器官，以快速测量组织血流量。测量过程非常方便，电极的无菌插入使临床应用成为可能。3）临床应用我们尝试用这种新型的热清除流量计测量支气管粘膜的组织血流量。临床应用需要对传感器进行改进。

1) A new heat-clearance flowmeter A new heat-clearance flowmeter was developed in order to measure tissue blood flow. The sensor was composed of copper-constantan thermocouples and a constantan heating wire wrapped around one of the two thermocouples. These configurations are placed inside two 10mm long stainless steel pipes, in diameter at 630um and 410um, respectively. An electric current through a constand current circuit was applied to the heater for a set period of time. The clearance curve was then measured.2) Animal experiment Four living sheep were used as specimen, and it was demonstrated that the clearance curve gradients and the volume of blood flow show a fairly high degree of correlation and there were no observal difference in the four specimen samples. Therefore, it seems clear that this method can be applied successfully to other animals or organs in order to measure tissue blood flow rapidly. The procedure of measurements is very convenient and aseptic insertion of the electrode makes the clinical application possible.3) Clinical application We tried to measure tissue blood flow at bronchial mucosa, using this new heat-clearance flow meter. Improvement of the sensor were required to be applied clinically.