DEVELOPMENT OF AN APPARATUS FOR MEASURING TISSUE BLOOD FLOW BY HEAT CLEARANCE CURVE

通过热间隙曲线测量组织血流量的装置的研制

• 批准号: 61870029
• 负责人: OKADA Akira
• 金额: $ 2.37万
• 依托单位: KANAZAWA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-61870029/
• 关键词: HEAT CLEARANCE; TISSUE BLOOD FLOW; SKIN BLOOD FLOW; HYDROGEN GAS CLEARANCE METOD; 冷水浸漬; 水素クリアランス法

For the quantative dynamic assessment of body surface circulation, we developed the prove incorporating a peltier stack and enabled its measutement. However, when the environment temperature is chenged largely, if has been impossible to assess tissue blood flow Uantitatively by this method. Therefore, in order to modify the apparatus for measuring tissue blood flow continuously under any condition, new probe was developed and the fundamental studies abour the measutement of human skin blood flow were carried out in the finger using the heat clearance curve. The results obtained were as follows.1) The gradient of heat clearance curvr on plates of various materials similar in the thermal conductivity to human skin was measuted. A highly positive cottrlation between the retmal conductivity of the material and their gradients was observed. New probe enables us to assess the gradient of heat cleatrance curve of tissues queatitatively.2) Its gradient gradually dectrased in parallel with the … More finger ischemia induced by inflation of a tourniguet, suggersting that the gradient varied with the change os finger blood flow and that its baseline was strady.3) A highly significant positive correlation was obtained between finger blood flow measured by the inhaled hydrogen clearance nethod and the gradient of heat cleatance curve. Accordingly, the absolute value of skin blood flow can be measured continuously and invasively in hymans.Using this systems, the peripheral circulatory function of workers who used vibrating tolls were studied at rest, and then the perepheral circulatory movements during and after cold water immersion were examined. Workers using vibration tools were devided into two groups;group with no sympton and group with Ranaud's phenomenon. The changes of finger blood flow of the group with no symptom showed cold vasuclar reaction, but those of the group with Raynaud's phenomenon did not show the reaction clearly. The newly developed system was useful in the elucidataion if its parhogenesis. Less

对于体表循环的定量动态评估，我们开发了结合珀耳帖堆栈的证明，并实现了其测量。然而，当环境温度变化较大时，用这种方法无法测定组织血流量。因此，为了改进现有的组织血流量连续测量装置，研制了新型探头，并利用热清除曲线在手指上进行了人体皮肤血流量测量的基础研究。主要结果如下：1）测量了与人体皮肤导热系数相近的各种材料平板的热清除曲率梯度。观察到材料的热电导率与它们的梯度之间的高度正相关。新探头使我们能够定量地评估组织热清除曲线的梯度。2）其梯度与组织热清除曲线的梯度平行地逐渐减小。 ...更多信息 结果表明：（1）氢气清除法测定的手指血流量与热清除曲线的梯度呈高度正相关;（2）氢气清除法测定的手指血流量与热清除曲线的梯度呈高度正相关。应用该系统对振动锤作业工人进行了安静状态下外周循环功能的研究，并对冷水浸泡前后外周循环运动进行了观察。将使用振动工具的工人分为无症状组和雷诺现象组。无症状组的指血流变化表现为冷血管反应，而雷诺现象组的指血流变化则表现不明显。新建立的系统有助于阐明其同源性。少

项目成果

OKADA,AKIRA: "MEASUTEMENT OF TISSUE BLOOD FLOW BY ANALYZING HEAT CLEARANCE CURVE" THE JAPANESE JOURNAL OF MEDICAL INSTUMENTATION. 58. (1988)

冈田晃：“通过分析热间隙曲线来测量组织血流”，日本医学仪器杂志。

岡田晃,中村秀喜,野原聖一: 医科器械学雑誌. (1988)

Akira Okada、Hideki Nakamura、Seiichi Nohara：医疗器械杂志 (1988)。

岡田晃,中村秀喜,野原聖一: 医科機械学雑誌.

Akira Okada、Hideki Nakamura、Seiichi Nohara：医学力学杂志。