DEVELOPMENT OF AN APPARATUS FOR MEASURING TISSUE BLOOD FLOW BY HEAT CLEARANCE CURVE

对于体表循环的定量动态评估，我们开发了包含peltier堆栈的证明，并使其测量成为可能。然而，当环境温度大幅度升高时，用这种方法定量评估组织血流量是不可能的。因此，为了改进该仪器，使其能够在任何条件下连续测量组织血流量，研制了新型探针，并利用热清除率曲线在手指中进行了人体皮肤血流量测量的基础研究。所得结果如下：1)测量热导率与人体皮肤相似的各种材料板上的热间隙曲线梯度。在材料的电导率和它们的梯度之间观察到高度正相关。新的探针使我们能够定量地评估组织热间隙曲线的梯度。2)随着止血带膨胀引起的手指缺血增加，其梯度逐渐减小，提示其梯度随手指血流量的变化而变化，其基线是均匀的。3)吸入氢清除率法测定的手指血流量与热清除率曲线梯度呈极显著正相关。因此，可以连续地、有创地测量处女膜皮肤血流量的绝对值。利用该系统研究了使用振动收费站的工人在休息时的外周循环功能，然后检测了冷水浸泡期间和之后的外周循环运动。使用振动工具的工人分为两组；无症状组和有雷诺氏现象组。无症状组的手指血流变化表现为冷血管反应，而有雷诺现象组的手指血流变化不明显。新建立的系统有助于阐明其发病机制。少

For the quantative dynamic assessment of body surface circulation, we developed the prove incorporating a peltier stack and enabled its measutement. However, when the environment temperature is chenged largely, if has been impossible to assess tissue blood flow Uantitatively by this method. Therefore, in order to modify the apparatus for measuring tissue blood flow continuously under any condition, new probe was developed and the fundamental studies abour the measutement of human skin blood flow were carried out in the finger using the heat clearance curve. The results obtained were as follows.1) The gradient of heat clearance curvr on plates of various materials similar in the thermal conductivity to human skin was measuted. A highly positive cottrlation between the retmal conductivity of the material and their gradients was observed. New probe enables us to assess the gradient of heat cleatrance curve of tissues queatitatively.2) Its gradient gradually dectrased in parallel with the … More finger ischemia induced by inflation of a tourniguet, suggersting that the gradient varied with the change os finger blood flow and that its baseline was strady.3) A highly significant positive correlation was obtained between finger blood flow measured by the inhaled hydrogen clearance nethod and the gradient of heat cleatance curve. Accordingly, the absolute value of skin blood flow can be measured continuously and invasively in hymans.Using this systems, the peripheral circulatory function of workers who used vibrating tolls were studied at rest, and then the perepheral circulatory movements during and after cold water immersion were examined. Workers using vibration tools were devided into two groups;group with no sympton and group with Ranaud's phenomenon. The changes of finger blood flow of the group with no symptom showed cold vasuclar reaction, but those of the group with Raynaud's phenomenon did not show the reaction clearly. The newly developed system was useful in the elucidataion if its parhogenesis. Less