Targeting CXCR4 to suppress virus-induced activation of plasmacytoid dendritic cells

靶向 CXCR4 抑制病毒诱导的浆细胞样树突状细胞激活

• 批准号: 409751703
• 负责人: Professor Dr. Jan Münch
• 金额: --
• 依托单位: Institut für Molekulare Virologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/409751703?language=en
• 关键词: Targeting; CXCR4; suppress; virus; induced

Our project focuses on plasmacytoid DC (pDC), which are the first line of defense against viruses due to their ability to produce massive amounts of type I IFN after sensing virus DNA or RNA. They are present at mucosal sites of HIV entry. Interestingly, natural amines, such as the semen component spermine, suppress the HIV-induced IFNα production by pDC via the receptor CXCR4, which is also a co-receptor for HIV infection. The mechanisms underlying pDC suppression via CXCR4 and the consequences for HIV transmission will be studied in Detail.

我们的项目集中在浆细胞样DC（pDC），这是抵御病毒的第一道防线，因为它们能够在感知病毒DNA或RNA后产生大量的I型IFN。它们存在于HIV进入的粘膜部位。有趣的是，天然胺，如精液成分精胺，通过受体CXCR4抑制HIV诱导的pDC产生IFNα，CXCR4也是HIV感染的辅助受体。将详细研究通过CXCR4抑制pDC的潜在机制以及HIV传播的后果。