Studies on stem cell factor receptor (c-kit) control of chronic inflammation

干细胞因子受体（c-kit）控制慢性炎症的研究

• 批准号: 41100262
• 负责人: Dr. Lena Wester Rosenlöf
• 金额: --
• 依托单位: Institut für Immunologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/41100262?language=en
• 关键词: Studies; stem; cell; factor; receptor

This project will elucidate the mechanism and biological importance of a recently identified gene, c-kit, that specifically control chronic inflammation in a rat model of rheumatoid arthritis (RA). Chronic inflammation is a hallmark of many population wide-spread diseases, e.g. RA, Multiple Sclerosis and Asthma. Therefore, it is of great importance to find a way to control the “chronicity component” of inflammation. Data, in this project, show that the mechanism and genetic regulation of chronic inflammation is different from acute inflammation. The c-kit gene is identified as a specific regulator of chronic inflammation. This project aims to confirm the finding in human material and reveal the mechanism behind the c-kit regulation. The goal is to find therapeutics that specifically can turn off chronic inflammation and find predisposing markers to identify patients that will benefit from this therapeutics.

本项目将阐明最近鉴定的基因c-kit的机制和生物学重要性，该基因特异性控制类风湿性关节炎（RA）大鼠模型中的慢性炎症。慢性炎症是许多人群广泛传播的疾病的标志，例如RA、多发性硬化症和哮喘。因此，寻找一种控制炎症“慢性成分”的方法具有重要意义。该项目的数据表明，慢性炎症的机制和遗传调节与急性炎症不同。c-kit基因被鉴定为慢性炎症的特异性调节因子。该项目旨在证实人体材料中的发现，并揭示c-kit调节背后的机制。我们的目标是找到可以特异性关闭慢性炎症的治疗方法，并找到易感标记物来识别将从这种治疗方法中受益的患者。