超音波心筋組織診断によるアドリアマイミン心臓障害の評価

超声心肌组织诊断评价阿霉素心脏损伤

• 批准号: 10770305
• 负责人: 長井 英夫
• 金额: $ 0.26万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Encouragement of Young Scientists (A)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10770305/
• 关键词: Echocardiography; Tissue characterization; Integrated backscatter; Anthracycline; Heart failure; echocardiography; tissue characterization; integrated backscatter; anthracycline; heart failare

平成10年度に超音波心筋組織診断が可能なように市販の超音波心エコー装置に改良を加え,アドリアマイシンを含むanthracycline系抗がん剤投与患者の心筋組織性状診断をIBを用いて行い,anthracycline系抗がん剤投与患者においては従来の心エコーで評価した心機能指標が正常にも関わらずIB指標が異常である症例がみられることを第63回日本循環器学会学術集会(1999年3月27〜29日,東京)で発表した.平成11年度は比較的単一のプロトコールで治療されている非ホジキンリンパ腫患者を対象に心筋組織性状診断を行い,アドリアマイシン投与量とIB指標,従来の心エコー指標を比較した.未治療群(C群)とアドリアマイシン治療群(L群,DXR総投与量≦200mg/m^2;M群,≦400mg/m^2;H群>400mg/m^2)において各群間で従来の心エコー指標には差がみられなかったが,IBの心周期変動(CV-IB)はアドリアマイシン総投与量の増加により低下し,C群,L群に比しH群で有意に低値であった.以上よりIBの解析により早期にアドリアマイシンによる心筋障害が検出できる可能性が示唆された.上記の要旨は第15回北陸心筋代謝研究会(2000年2月26日,金沢)において発表した.現在論文化の準備を進めている.

In Pingcheng, there may be some changes in the ultrasonic cardioplegia device in Pingcheng in the year of 10. It is possible to improve the equipment of the ultrasonic cardioplegia device in Pingcheng, which contains the resistance of the anthracycline system to the heart tissue of the patient, and the character of the heart muscle tissue of the patient. IB may be used to improve the performance. The Department of Anti-inflammatory Therapy (anthracycline) is responsible for the diagnosis and treatment of chronic heart disease. The cardiocardiogram can indicate that the patients are suffering from normal symptoms. IB refers to the cases of common symptoms. Please go back to the Art Fair of the Environmental Instruments Society of Japan (March 27-29, 1999). For the first time in Pingcheng 11, there was a significant increase in the number of patients who suffered from heart tissue damage in the first half of the year. The heart tissue characteristics of the patients were broken, and their heart tissue traits were measured by IB. Untreated group (group C). Group L, DXR investment and quantity 200mg/ m ^ 2; M group, 400mg/ m ^ 2; H group & gt 400mg/ m ^ 2) Group C, Group L are intentionally lower than Group H. Group C, Group L are intentionally lower than Group H, which means that people in Group C and Group L are intentionally lower than those in Group H. 400mg/ m ^ 2) Group C, Group L are intentionally lower than Group H in terms of low levels of investment and volume. The above "IB" analysis shows that there is a possibility of instigation in the early stage. In the last chapter, the 15th back to the North "Xinjin Dai" Research Society (February 26, 2000, Jinyi) will be held in Beijing. Now we are going to discuss the culture in preparation for further discussion.