Organocatalytic Cycloaddition Reactions and Mechanistic Investigations

在众多的有机催化反应中，亲核型有机催化剂催化的环加成反应因其反应效率高、反应条件非常温和、催化剂易于回收等优点，是获得碳和杂环化合物最常用、最有效的方法之一，得到了较好的发展。然而，导致高区域选择性和立体选择性的机制仍然缺乏系统的研究。在中德联合研究项目中，我们将采用实验和理论相结合的方法研究有机催化环加成反应及其相关机理，并进一步开发新的反应模式，探索新的底物和机制，这将有利于天然产物核心结构的合成。所涉及的研究小组方法的多样性预计将提供特别高的协同作用。

Among a large number of organocatalytic reactions, cycloaddition reactions catalyzed by nucleophilic organocatalysts have been well developed, since they represent one of the most commonly used and efficient methods to access carbo- and heterocyclic compounds due to their high efficiency, very mild reaction conditions, and easy recycling of catalysts. However, the mechanisms leading to high regio- and stereoselectivities still lack systematic research. Within this Joint Sino-German Research Project, we intend to investigate organocatalytic cycloaddition reactions and their related mechanisms using a combination of experimental and theoretical techniques, and further to develop new reaction modes and to explore new substrates and mechanisms, which will benefit the synthesis of core structures of natural products. The methodological diversity of the involved research groups is expected to offer particularly high synergies.