Organocatalytic Cycloaddition Reactions and Mechanistic Investigations

有机催化环加成反应及机理研究

基本信息

项目摘要

Among a large number of organocatalytic reactions, cycloaddition reactions catalyzed by nucleophilic organocatalysts have been well developed, since they represent one of the most commonly used and efficient methods to access carbo- and heterocyclic compounds due to their high efficiency, very mild reaction conditions, and easy recycling of catalysts. However, the mechanisms leading to high regio- and stereoselectivities still lack systematic research. Within this Joint Sino-German Research Project, we intend to investigate organocatalytic cycloaddition reactions and their related mechanisms using a combination of experimental and theoretical techniques, and further to develop new reaction modes and to explore new substrates and mechanisms, which will benefit the synthesis of core structures of natural products. The methodological diversity of the involved research groups is expected to offer particularly high synergies.
在众多的有机催化反应中,亲核有机催化剂催化的环加成反应因其反应效率高、反应条件温和、催化剂易回收而成为最常用和最有效的碳杂环化合物合成方法之一。然而,导致高区域和立体选择性的机制仍然缺乏系统的研究。在这个中德联合研究项目中,我们打算用实验和理论相结合的方法研究有机催化环加成反应及其相关机理,并进一步开发新的反应模式,探索新的底物和机理,这将有助于合成天然产物的核心结构。预计有关研究小组的方法多样性将提供特别高的协同增效作用。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Reactivities of allenic and olefinic Michael acceptors towards phosphines.
  • DOI:
    10.1039/d1cc06786a
  • 发表时间:
    2022-02
  • 期刊:
  • 影响因子:
    4.9
  • 作者:
    Feng An;Harish Jangra;Yin Wei;M. Shi;H. Zipse;A. Ofial
  • 通讯作者:
    Feng An;Harish Jangra;Yin Wei;M. Shi;H. Zipse;A. Ofial
Phosphine-catalyzed [3 + 2] annulation of 2-aminoacrylates with allenoates and mechanistic studies
  • DOI:
    10.1039/d0cy00092b
  • 发表时间:
    2020-06
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Xiao-yun Wu;Hou Gui;Harish Jangra;Yin Wei;H. Zipse;M. Shi
  • 通讯作者:
    Xiao-yun Wu;Hou Gui;Harish Jangra;Yin Wei;H. Zipse;M. Shi
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Privatdozent Dr. Armin Ofial其他文献

Privatdozent Dr. Armin Ofial的其他文献

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{{ truncateString('Privatdozent Dr. Armin Ofial', 18)}}的其他基金

Reactivities of electron-deficient arenes
缺电子芳烃的反应活性
  • 批准号:
    530072453
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
    Research Grants

相似海外基金

New Catalysts and Strategies for Selective C–H Functionalization and Cycloaddition Reactions
选择性 C–H 官能化和环加成反应的新催化剂和策略
  • 批准号:
    10622182
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Metal-Catalyzed Cycloaddition Reactions of Aziridines
金属催化氮丙啶的环加成反应
  • 批准号:
    560069-2021
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Postgraduate Scholarships - Doctoral
Catalytic Cycloaddition Reactions and Their Applications
催化环加成反应及其应用
  • 批准号:
    2054845
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Metal-Catalyzed Cycloaddition Reactions of Aziridines
金属催化氮丙啶的环加成反应
  • 批准号:
    560069-2021
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
    Postgraduate Scholarships - Doctoral
Metal­-Catalyzed Cycloaddition Reactions of Aziridines
金属催化氮丙啶的环加成反应
  • 批准号:
    553910-2020
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Master's
Studies of high pressure effects in cycloaddition reactions
环加成反应中高压效应的研究
  • 批准号:
    550404-2020
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
    University Undergraduate Student Research Awards
Metal-Catalyzed Cycloaddition Reactions of Aziridines
金属催化氮丙啶的环加成反应
  • 批准号:
    542794-2019
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Master's
Organic Synthesis: Investigation on Novel Cycloaddition Reactions of Vinylaziridines
有机合成:乙烯基氮丙啶新型环加成反应的研究
  • 批准号:
    541784-2019
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    University Undergraduate Student Research Awards
Selective Catalytic [3+n]-Cycloaddition Reactions with Vinyldiazo Compounds
乙烯基重氮化合物的选择性催化 [3 n]-环加成反应
  • 批准号:
    1763168
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Cycloaddition Reactions of Active Cyclic Frustrated Lewis Pairs
活性环状受阻路易斯对的环加成反应
  • 批准号:
    411668360
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
    Research Grants
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