Quantitative Magnetresonanztomographie als Schlüsseltechnologie in den Lebenswissenschaften

定量磁共振成像作为生命科学的关键技术

• 批准号: 412741675
• 负责人: Professor Dr. Ingolf Sack
• 金额: --
• 依托单位: Klinik für Radiologie (mit dem Bereich Kinderradiologie) (CCM)
• 依托单位国家: 德国
• 项目类别: Workshops for Early Career Investigators
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/412741675?language=en
• 关键词: Quantitative; Magnetresonanztomographie; als; Schl; sseltechnologie

The biophysical properties of biological tissues are key to our understanding of various pathophysiological processes. Insight into these properties will open up possibilities for longterm disease control and the development of new diagnostic tools or even of curative therapies. Magnetic resonance (MR) technologies hold a unique position among medical imaging methods: they can answer both clinical-diagnostic and fundamental research questions. MR imaging (MRI) and MR spectroscopy are exceptionally useful tools for addressing a wide range of scientific questions - from molecular mechanisms to multiscale biophysical interactions in living tissues. In radiological routine, MRI is used predominantly as a nonquantitative imaging modality for the visual analysis of pathological organ changes. However, it imposes fundamental challenges in daily routine such as long training times, uncertain diagnoses, and limited comparability of MR images in multicenter studies and follow-up examinations. The planned workshop ‘Nachwuchsakademie Medizintechnik (NAMT)’ will introduce young scientists to the field of quantitative MRI and make them aware of the potential of measuring and analyzing biophysically based and quantitative tissue parameters. The goal of the workshop is to get excellent young scientists interested in the further development of quantitative MRI as a key technology for the identification and validation of constitutive and system-independent tissue parameters. The gain in knowledge will contribute to a better understanding of disease-specific biochemical and biophysical mechanisms and will improve diagnosis and therapies. Importantly, the NAMT workshop will enable young scientists to develop their own independent research profiles early in their careers and to establish professional networks with experts from academic institutions and industry. The interdisciplinary interaction between experts in life sciences, mathematics, informatics, and medicine will foster the implementation of improved quantitative MRI methods in clinical routine. The workshop also includes a training in proposal writing and project management, aimed at enabling young scientists to successfully acquire third-party research funding without a long learning phase. It mainly targets students in the final phase of their PhD projects as well as young postdoctoral scientists.

生物组织的生物物理特性是我们理解各种病理生理过程的关键。深入了解这些特性将为长期疾病控制和开发新的诊断工具甚至治愈性疗法开辟可能性。磁共振（MR）技术在医学成像方法中占有独特的地位：它们可以回答临床诊断和基础研究问题。磁共振成像（MRI）和磁共振波谱是非常有用的工具，用于解决广泛的科学问题-从分子机制到活组织中的多尺度生物物理相互作用。在常规放射学检查中，MRI主要用作非定量成像方式，用于病理器官变化的视觉分析。然而，它在日常工作中带来了根本性的挑战，例如长时间的训练、不确定的诊断以及多中心研究和随访检查中MR图像的可比性有限。计划中的研讨会“Nachwuchsakademie Medizintechnik（NAMT）”将向年轻科学家介绍定量MRI领域，并使他们意识到测量和分析基于生物病理学和定量组织参数的潜力。该研讨会的目标是让优秀的年轻科学家对定量MRI的进一步发展感兴趣，作为识别和验证组成和系统无关组织参数的关键技术。知识的增加将有助于更好地了解疾病的具体生化和生物物理机制，并将改善诊断和治疗。重要的是，NAMT讲习班将使年轻科学家能够在职业生涯早期发展自己的独立研究概况，并与学术机构和工业界的专家建立专业网络。生命科学、数学、信息学和医学专家之间的跨学科互动将促进在临床常规中实施改进的定量MRI方法。讲习班还包括一次提案撰写和项目管理培训，旨在使青年科学家能够成功获得第三方研究资金，而无需经过漫长的学习阶段。它主要针对博士项目最后阶段的学生以及年轻的博士后科学家。