Role of NG2-glia in different injury paradigms (A08*)

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We could show that acute invasive brain trauma leads to a rapid and heterogeneous NG2-glia response, not only with morphological changes but also with an increase in number. Genetic ablation of reactive NG2-glia resulted in effects on wound closure that we are currently further analyzing. We also identified a NG2-glia subset expressing GPR17, which although not differentiating under physiological conditions, after injury reacts with immediate differentiation, suggesting that these cells represent a cell reservoir responsible for brain repair. Here, we hypothesize that reactive NG2-glia are important for repair and wound closure after stab and traumatic brain injuries and that the GPR17-protein itself as well as the GPR17+ subset of NG2-glia are necessary modulators of the outcome of brain injury.