Role of NG2-glia in different injury paradigms (A08*)

NG2-胶质细胞在不同损伤范例中的作用 (A08*)

• 批准号: 414059600
• 金额: --
• 依托单位: Studiengang Molecular and Translational Neuroscience
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/414059600?language=en
• 关键词: Role; NG2; glia; different; injury

We could show that acute invasive brain trauma leads to a rapid and heterogeneous NG2-glia response, not only with morphological changes but also with an increase in number. Genetic ablation of reactive NG2-glia resulted in effects on wound closure that we are currently further analyzing. We also identified a NG2-glia subset expressing GPR17, which although not differentiating under physiological conditions, after injury reacts with immediate differentiation, suggesting that these cells represent a cell reservoir responsible for brain repair. Here, we hypothesize that reactive NG2-glia are important for repair and wound closure after stab and traumatic brain injuries and that the GPR17-protein itself as well as the GPR17+ subset of NG2-glia are necessary modulators of the outcome of brain injury.

我们可以证明急性侵袭性脑损伤导致ng2 -胶质细胞的快速和异质反应，不仅形态改变，而且数量增加。基因消融反应性ng2胶质细胞对伤口愈合的影响，我们目前正在进一步分析。我们还发现了一个表达GPR17的ng2胶质细胞亚群，尽管在生理条件下不分化，但在损伤后会立即分化，这表明这些细胞代表了负责脑修复的细胞库。在这里，我们假设反应性ng2 -胶质细胞在刺伤和创伤性脑损伤后的修复和伤口闭合中起重要作用，并且GPR17蛋白本身以及ng2 -胶质细胞的GPR17+亚群是脑损伤结果的必要调节剂。