CFTR and TMEM16A/F in polycystic kidney disease and metabolic alkalosis (A03)

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CFTR and TMEM16A/F are chloride ion channels that are strongly expressed in the kidney. Their function in the kidney remains poorly understood. In this project, we use genetically modified mouse models to investigate the role of CFTR and TMEM16A/F for renal cyst formation as well as the signaling pathways involved. Moreover, we will explore the importance of CFTR, TMEM16A, and SLC26A4 (pendrin) during metabolic alkalosis in vivo using kidney-specific CFTR, TMEM16A/F, and SLC26A4 knockout mice. The expected results should provide important hints to the role of these Cl- channels in the formation of renal cysts and metabolic alkalosis in cystic fibrosis.