Electrochemically enabled (enantioselective) nickel-catalyzed sp³ C-H α-arylation of (a)cyclic heterohydrocarbons

该研究项目的重点是开发一种电化学（对映选择性）镍催化的（a）环状杂烃的sp3 C-H α-芳基化反应。根据吉田之前的出版物，电化学生成的α-自由基吡咯烷将在镍催化下与芳基卤交叉偶联，得到所需的2-芳基吡咯烷。在优化了反应参数后，对底物范围、使用手性配体生成对映体纯产物以及使用各种其他（a）环杂烃进行了阐述。交叉耦合的基本机制将进行调查，阿利亚是动力学同位素效应。通过在多克规模上进行反应，展示了已发展的sp3 C-H α-芳基化反应在有机合成中的应用。

The research project focusses on the devolvement of an electrochemically enabled (enantioselective) nickel catalyzed sp3 C-H α-arylation of (a)cyclic heterohydrocarbons.According to previous publications by Yoshida, electrochemically generated α-radically pyrrolidines are to be cross-coupled with arylhalides under nickel-catalysis to yield the desired 2-arylpyrrolidines. After optimization of the reaction parameters, the substrate scope, use of chiral ligands to generate enantiopure products, as well as the use of various other (a)cyclic heterohydrocarbons is to be elaborated. The underlying mechanism of the cross-coupling will be investigated, inter alia by kinetic isotope effects. By carrying out the reaction on a multigram scale, the use of the developed sp3 C-H α-arylation in organic synthesis is to be displayed.