Electrochemically enabled (enantioselective) nickel-catalyzed sp³ C-H α-arylation of (a)cyclic heterohydrocarbons

(a)环状杂烃的电化学活化（对映选择性）镍催化 sp 3 C-H α-芳基化

• 批准号: 417040718
• 负责人: Dr. Johannes Teske
• 金额: --
• 依托单位: Department of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/417040718?language=en
• 关键词: Electrochemically; enabled; enantioselective; nickel; catalyzed

The research project focusses on the devolvement of an electrochemically enabled (enantioselective) nickel catalyzed sp3 C-H α-arylation of (a)cyclic heterohydrocarbons.According to previous publications by Yoshida, electrochemically generated α-radically pyrrolidines are to be cross-coupled with arylhalides under nickel-catalysis to yield the desired 2-arylpyrrolidines. After optimization of the reaction parameters, the substrate scope, use of chiral ligands to generate enantiopure products, as well as the use of various other (a)cyclic heterohydrocarbons is to be elaborated. The underlying mechanism of the cross-coupling will be investigated, inter alia by kinetic isotope effects. By carrying out the reaction on a multigram scale, the use of the developed sp3 C-H α-arylation in organic synthesis is to be displayed.

该研究项目的重点是在（a）循环杂质氢化物的（a）Yoshida的先前出版物中催化（a）（a）循环杂质的SP3 c-Hα-酰亚其化的镍的散布，催化了yoshiDA的出版​​物。 2-芳基吡咯烷。在优化反应参数后，底物范围，使用手性配体来生成对映射产物，以及使用各种其他（a）循环杂质杂质的使用。交叉耦合的基本机制将通过动力学同位素效应进行研究。通过在多型量表上进行反应，将显示在有机合成中使用的SP3 C-Hα-酰化。