Mechanisms of tumorigenesis and metastasis formation by the phos-phatase PRL-3 (B13#)

磷酸酶 PRL-3 (B13) 的肿瘤发生和转移形成机制

• 批准号: 418064137
• 金额: --
• 依托单位: Zentrum für Biologische Signalstudien (BIOOS)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/418064137?language=en
• 关键词: Mechanisms; tumorigenesis; metastasis; formation; phos

The phosphatase of regenerating liver (PRL)-3 promotes cell proliferation, migration, disruption of epithelial architecture, and invasion, and is found highly expressed in many carcinomas and metastases. To date, the reported molecular mechanisms cannot explain all phenotypes in full. This project addresses this challenge by studying the molecular mechanisms of PRL-3 in different cell types from the same genetic background ex- and in vivo. Together, the aim is to understand PRL-3-mediated phenotypes on a mechanistic level, and to give insights into possible drug targeting of PRL-3 and processes affected by it.

再生肝磷酸酶(PRL)-3促进细胞增殖、迁移、破坏上皮结构和侵袭，在许多肿瘤和转移瘤中都有高表达。到目前为止，已报道的分子机制还不能完全解释所有的表型。本项目通过从相同的体内外遗传背景研究PRL-3在不同细胞类型中的分子机制来解决这一挑战。总之，目的是在机制水平上了解PRL-3介导的表型，并深入了解PRL-3可能的药物靶向及其影响的过程。