Mechanisms of tumorigenesis and metastasis formation by the phos-phatase PRL-3 (B13#)

再生肝磷酸酶(PRL)-3促进细胞增殖、迁移、破坏上皮结构和侵袭，并在许多癌症和转移中被发现高表达。迄今为止，报道的分子机制不能完全解释所有表型。本项目通过研究PRL-3在具有相同遗传背景的不同细胞类型中的分子机制来解决这一挑战。总之，目的是在机制水平上了解PRL-3介导的表型，并深入了解PRL-3可能的药物靶向及其影响的过程。

The phosphatase of regenerating liver (PRL)-3 promotes cell proliferation, migration, disruption of epithelial architecture, and invasion, and is found highly expressed in many carcinomas and metastases. To date, the reported molecular mechanisms cannot explain all phenotypes in full. This project addresses this challenge by studying the molecular mechanisms of PRL-3 in different cell types from the same genetic background ex- and in vivo. Together, the aim is to understand PRL-3-mediated phenotypes on a mechanistic level, and to give insights into possible drug targeting of PRL-3 and processes affected by it.