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誘電分散法による緑内障定量的診断法の開発

介电色散法定量青光眼诊断方法的开发

基本信息

批准号：
09771439
负责人：
渡邊牧夫
金额：
$ 1.02万
依托单位：
Kochi Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Encouragement of Young Scientists (A)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

申請者は,誘電分散理論に基づき,線維柱帯の房水排出機能を定量的に評価し,臨床応用への道を探ることを目的としている.前年度から引き続き,本年度は誘電分散法による緑内障定量的診断法開発の前段階として,摘出眼球およびin vivo眼球を用いての誘電測定および誘電解析を行った.開放隅角緑内障の発生原因となる線維柱帯の微細構造の変化と,それに伴う房水排出機能の変化を,交流電場中での誘電挙動の変化として捉え得る可能性は大きい.まず,摘出眼球を用いた実験結果で,眼圧に無関係に角膜輪部から0.5mm強膜側の直上で,線維柱帯の誘電挙動が観察可能であり,線維柱帯での房水のフローを増加させると,さらなる分散現象のブロード化を認めたことから,本法により観察可能な線維柱帯の誘電挙動は,その微細構造のみでなく,房水排出機能をも反映している可能性が証明された.さらに,in vivo眼球を用いての実験においても,やはり眼圧に無関係に角膜輪部から0.5mm強膜側の直上で,線維柱帯の誘電挙動が観察可能であったが,in vivo眼球では,心拍に伴う眼圧の脈波の影響を受けるため,誘電測定データにおいても,脈波に伴うデータのバラツキが観察された.この脈波に伴うデータのバラツキのため,直接raw dataから得た誘電率・導電率をloss tangentに変換した場合,やはりデータのバラツキは避けられない.そこで一旦,2項Cole-Cole式でカーヴ・フィッティングをした後,即ち,誘電分散理論に基づき,いわばスムージングした後,loss tangent表示をする事により,in vivo眼球においても線維柱帯の誘電挙動が観察可能であった.今後は,in vivo眼球で実験的緑内障を作製して,線維柱帯の房水排出機能の変化を調べる予定である.

The applicant is responsible for the basis of the dispersion theory, the aqueous humor is drained out of the machine by the column, and the bed is used to explore the purpose. In the previous year, it was introduced, and in this year, the dispersion method was used to determine the quantity of cataract. The anterior segment of the cataract was cut off, and the eyeballs were removed, and the in vivo eyeballs were measured and analyzed. The cause of cataract in the corner is caused by microsurgery, which is associated with the mechanism of aqueous humor discharge. in the AC power field, there is a great possibility that the cataract will be successful. The eyeball was extracted and the results were obtained. The cornea of the eyeball was removed. The 0.5mm membrane was placed on the cornea of the eye. The tension of the cornea was detected in the upper part of the cornea. It is possible to monitor the movement of the cornea. It is possible to monitor the movement of the cornea. It is possible to monitor the operation of the column. The system is designed to reflect the possibility of aqueous humor discharge. The in vivo eyeball is used to detect the tension of the eye, the cornea of the eye, the 0.5mm membrane of the cornea, the movement of the eye, the movement of the eye, the wave of the eye, the eye. As a result, you can get the electricity rate of electricity generation by raw data directly. You can get the electricity rate of electricity by the combination of loss tangent. As soon as the two Cole- Cole tests are completed, that is, the dispersion theory is very important, and after the information is changed, loss tangent indicates that the information is not correct, and the in vivo eyeball monitoring system may be sensitive. In the future, the cataract of in vivo eyeball cataract will be affected, and the aqueous humor discharge mechanism will improve the prediction of aqueous humor drainage.