放射線治療前後における唾液腺の超音波断層所見と臨床症状の変化に関する研究

放疗前后唾液腺超声横断面表现及临床症状变化研究

• 批准号: 10771121
• 负责人: 加藤 徳紀
• 金额: $ 1.15万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Encouragement of Young Scientists (A)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10771121/
• 关键词: 唾液腺; 放射線治療; 超音波断層撮影

放射線治療前後の唾液腺の変化を超音波断層撮影(東芝製SSA340A・8MHz電子リニア探触子)により評価することを目的に、ボランテア10人(28〜45才)における顎下腺および耳下腺の検討を行った。まずは大きさに関して、顎下腺の前後/左右/上下径は平均37.4/33.8/21.8mmであった。耳下腺では、深部への音波の減衰と副腺の有無等による個体差が大きかったため計測は困難であった。内部エコーに関しては、いずれも均一なエコー強度で、皮下脂肪識より低く周囲筋組織より高いエコー強度を呈していた。腺体内の血流に関して、顎下腺では顔面動脈からの分枝となる腺枝が流速レンジ0.03m/Secにおいて最も明瞭に確認でき、唾液分泌試験後では同一断面で血流面積の占める割合が平均4.92倍に増加した。耳下腺では外頚動脈は確認できるが、腺体内に分布する分枝は流速レンジを低くしても認められず、唾液分泌試験後でも指摘できなかった。以上より、放射線治療前後の唾液腺の評価に関しては、大きさや血流の変化は顎下腺で検討し、内部エコーの変化は顎下腺と耳下腺の両方で検討することとした。放射線治療患者は、2〜3年前に耳下腺と顎下腺を含めた頭頚部領域に外照射total60Gyを施行された5人を対象としたが、今回は放射線治療中の症例や綿密なプロトコールに基づいた検討は行わなかった。顎下腺は、5人中4例で正常より縮小しており、内部エコーは変化無いか、わずかに低下する傾向が認められた。腺体内の血流に関しては、平常時にはボランテアと同じ流速レンジで腺枝が明瞭に認められたが、唾液分泌刺激による血流面積の増加の割合は少なかった。耳下腺に関しては、内部エコーに大きな変化は認められなかった。しかし、いずれの症例も治療前の所見が無いため、治療前後における変化の検討は困難であった。

Changes of salivary glands before and after radiation therapy were examined by ultrasonic tomography (Toshiba SSA340A·8MHz electronic probe). The average diameter of the submandibular gland is 37.4/33.8/21.8mm. Ear gland, deep gland, sound wave attenuation, accessory gland, individual difference, measurement difficulty Internal fat is low in muscle tissue and high in strength. The blood flow in the gland and the submandibular gland increased by an average of 4.92 times after the blood flow in the same section was confirmed by the flow velocity of 0.03 m/Sec and salivary secretion test. The auricular gland is divided into two parts: the outer artery is divided into two parts: the inner part is divided into two parts: the lower part is divided into two parts: the inner part is divided into three parts: the outer artery is divided into two parts: the inner part is divided into three parts: the outer artery is divided into two parts: the inner part is divided into three parts: the outer artery is divided into two parts: the inner part is divided into three parts: the outer artery is divided into four parts: the inner part is divided into three parts: the inner part is divided into four parts: the outer artery is divided into four parts: the inner part is divided into four parts: the inner part is divided into four parts: the outer artery is divided into four parts: the inner part is divided into The above results show that the salivary gland changes before and after radiation therapy, and the changes of blood flow in the submandibular gland, the changes of internal cavity in the submandibular gland and the changes of ear gland are related to the changes of salivary gland and ear gland. The radiation therapy patients were treated with external radiation for a total of 60Gy 2 ~ 3 years ago, and the radiation therapy patients were treated with external radiation for a total of 60Gy. 4 out of 5 cases of mandibular glands were normal, 4 cases of mandibular glands were normal, and 4 cases of mandibular glands were normal. The blood flow in the gland is related to the normal time, the flow rate is the same, the gland branch is clear, the saliva secretion is stimulated, the blood flow area is increased, and the cut is reduced. The ear gland is closed, the inner part is big, the inner part is big, the inner part is big. Before and after treatment, the symptoms were found to be difficult.