Insulin resistance, diabetes and metabolic liver diseases in acute myocardial infarction (B12)

急性心肌梗死中的胰岛素抵抗、糖尿病和代谢性肝病（B12）

• 批准号: 418697689
• 金额: --
• 依托单位: Institut für Klinische Diabetologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/418697689?language=en
• 关键词: Insulin; resistance; diabetes; metabolic; liver

This project aims at characterizing the role of insulin resistance, typical for type 2 diabetes, in cardiac and systemic metabolism and organ crosstalk in patients with STEMI. This collaboration of cardiologists and diabetologists will enable concerted state-of-art analysis of heart function and pathogenic mechanisms (energy metabolism, inflammation) including magnetic resonance. This project has a key role within this CRC for detecting subphenotypes allowing for risk stratification of these patients with - at present - worse outcome and by serving as platform for experimental projects to identify metabolic targets for diagnostic and therapeutic interventions.

该项目旨在描述典型的2型糖尿病胰岛素抵抗在STEMI患者心脏和全身代谢以及器官串扰中的作用。心脏病专家和糖尿病专家的合作将使包括磁共振在内的心脏功能和致病机制（能量代谢、炎症）的最先进分析成为可能。该项目在该CRC中具有关键作用，可以检测亚表型，从而对这些目前预后较差的患者进行风险分层，并作为实验项目的平台，确定诊断和治疗干预的代谢靶点。