Stimulus-specific mechanical adaptation in the inner ear during repetitive sound stimulation

重复声音刺激期间内耳的刺激特异性机械适应

• 批准号: 423692108
• 负责人: Professor Dr. Manfred Kössl
• 金额: --
• 依托单位: Institut für Zellbiologie und Neurowissenschaft
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/423692108?language=en
• 关键词: Stimulus; specific; mechanical; adaptation; inner

The term ‘Stimulus specific adaptation’ (SSA) addresses neuronal mechanisms of novelty detection in the central auditory system. The response strength of individual auditory neurons in cortex can depend on the probability of occurrence of the evoking stimulus. In this regard, ‘deviant’ stimulus frequencies that are only rarely presented can evoke larger spike activity than more often presented ‘standard’ stimulus frequencies. It also has been shown that a descending efferent projection from the cortex is involved in frequency related SSA found in auditory thalamus or inferior colliculus. In the cochlea, adaptation-like phenomena on the level of hair cell activity and otoacoustic emissions have been investigated, in particular concerning the role of the efferent olivocochlear projections. So far, the possible relation or contribution of cochlear adaptation to central auditory SSA has not been studied. The present projects wants to fill this gap. We developed a paradigm to measure frequency specific adaptation of distortion-product-otoacoustic emissions (DPOAE). We will quantify components of SSA in DPOAEs and study the contribution of efferent activity by concomitant contralateral acoustic stimulation. We also will assess if cochlear SSA depends on the behavioural relevance of certain stimulus frequencies that are used for communication or for active echolocation in awake bats.

刺激特异性适应(SSA)一词阐述了中枢听觉系统中新颖性检测的神经元机制。皮层中单个听觉神经元的反应强度取决于诱发刺激发生的概率。在这一点上，很少出现的“异常”刺激频率可以比更经常出现的“标准”刺激频率引起更大的尖峰活动。也有研究表明，在听觉丘脑或下丘发现的频率相关的SSA与皮层的下行传出投射有关。在耳蜗中，毛细胞活动和耳声发射水平上的适应样现象已经被研究，特别是关于传出的橄榄耳蜗投射的作用。到目前为止，耳蜗声适应与中枢性听觉SSA之间的关系或作用还没有被研究过。目前的项目希望填补这一空白。我们开发了一种范式来测量失真产物耳声发射(DPOAE)的频率特异性适应。我们将量化DPOAES中SSA的成分，并研究伴随对侧声刺激的传出活动的贡献。我们还将评估耳蜗SSA是否取决于某些刺激频率的行为相关性，这些频率用于清醒蝙蝠的交流或主动回声定位。