Novel Sodium Ion Channel Modulators From Australian Cephalopods.

来自澳大利亚头足类动物的新型钠离子通道调节剂。

• 批准号: DP0663485
• 负责人: Prof Robert Capon
• 金额: $ 20.08万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0663485
• 关键词: Novel; Sodium; Ion; Channel; Modulators

Many Australian cephalopods (octopuses, squids, cuttlefishes and nautiluses) use potent toxins to rapidly paralyse diverse prey and defend against predators. These toxins act by the efficient blocking of ion channels critical to the transmission of nerve impulses. Knowledge of these toxins can lead to safer and better drugs for the relief of chronic pain.

许多澳大利亚头足类动物（章鱼、鱿鱼、墨鱼和鹦鹉螺）使用强效毒素迅速麻痹各种猎物，防御捕食者。这些毒素通过有效阻断对神经冲动传输至关重要的离子通道而起作用。对这些毒素的了解可以帮助我们研制出更安全、更好的药物来缓解慢性疼痛。