Mode of action of rhodomyrtone (Rom) and synthesized derivatives and studying the resistance mechanism mediated by FarE / FarR (A04)

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Rhodomyrtone (Rom) is an antibiotic that is active against many multi-resistant Gram-positive bacteria. A Rom-resistant Staphylococcus aureus mutant (RomR) has been isolated. Our preliminary studies suggest that FarR (a regulator) and FarE (a proposed fatty acid efflux pump) are causative for the resistance. Here, we want to study how FarE and FarR mediate resistance to Rom and probably other antibiotics. The chemical synthesis of Rom-derivatives is crucial to unravel the FarE substrate specificity.