Mode of action of rhodomyrtone (Rom) and synthesized derivatives and studying the resistance mechanism mediated by FarE / FarR (A04)

紫桃香酮 (Rom) 及其合成衍生物的作用方式及 FarE / FarR 介导的耐药机制研究 (A04)

• 批准号: 425787033
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/425787033?language=en
• 关键词: Mode; action; rhodomyrtone; Rom; synthesized

Rhodomyrtone (Rom) is an antibiotic that is active against many multi-resistant Gram-positive bacteria. A Rom-resistant Staphylococcus aureus mutant (RomR) has been isolated. Our preliminary studies suggest that FarR (a regulator) and FarE (a proposed fatty acid efflux pump) are causative for the resistance. Here, we want to study how FarE and FarR mediate resistance to Rom and probably other antibiotics. The chemical synthesis of Rom-derivatives is crucial to unravel the FarE substrate specificity.

红柳酮（Rom）是一种对多种多重耐药革兰氏阳性细菌有效的抗生素。一株抗罗姆金黄色葡萄球菌突变体（RomR）已被分离。我们的初步研究表明，FarR（一种调节剂）和FarE（一种脂肪酸外排泵）是导致耐药的原因。在这里，我们想研究FarE和FarR如何介导对Rom和其他抗生素的耐药性。rom衍生物的化学合成对于揭示FarE底物特异性至关重要。