Horizontal transfer, evolution, and cellular integration of Staphylococcus antibiosis islands (SAbIs) (B04)

葡萄球菌抗菌岛 (SAbIs) 的水平转移、进化和细胞整合 (B04)

• 批准号: 425876713
• 金额: --
• 依托单位: Lehrstuhl für Infektionsbiologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/425876713?language=en
• 关键词: Horizontal; transfer; evolution; cellular; integration

We recently described that staphylococcal species produce a variety of antibacterial compounds. The responsible gene clusters show signs of mobility and we suggest to term them SAbIs. We will identify families of SAbIs and investigate the routes and frequency of SAbI transfer. Using in vitro evolution experiments and metabolomics/genomics approaches, we will investigate adaptation processes that mediate producer resistance and metabolic fluxes that optimize fitness in SAbI recipients. The project will deliver novel insights into physiologic and metabolic bottlenecks as well as associated adaptations, shaping the diversity of compounds produced within bacterial communities.

我们最近描述了葡萄球菌种类产生多种抗菌化合物。相关基因簇表现出流动性的迹象，我们建议将其命名为sabi。我们将确定SAbI家族，并调查SAbI转移的路线和频率。利用体外进化实验和代谢组学/基因组学方法，我们将研究调节生产者抗性和代谢通量的适应过程，从而优化SAbI受体的适应性。该项目将提供关于生理和代谢瓶颈以及相关适应的新见解，塑造细菌群落内产生的化合物的多样性。