Amphiphilic Fouling-Resistant Surfaces Based on Janus Particles

基于 Janus 颗粒的两亲性防污表面

基本信息

项目摘要

Biofilm formation on materials surfaces – biofouling – has significant economic impact on a wide range of applications and industries. Fouling-resistant surfaces were recently demonstrated to be accessible from coatings of block copolymers that combine hydrophilic and hydrophobic components and form nano-scaled chemical domains with opposing surface energies (amphiphilic surfaces). However, in this approach neither the topography (a parameter that is known to strongly influence biofouling) nor the size and spacing of the chemical domains can be efficiently controlled and/or varied. Systematically exploring the effect of chemical domain size and topography of amphiphilic surfaces on biofouling could shed light on the interplay of these parameters on bioadhesion processes and provide unprecedented levels of fouling resistance.The proposed project therefore aims at introducing a new, scalable strategy for the design of amphiphilic surfaces with controlled fouling resistance using polymer-functionalized colloidal particles as surface-immobilized building blocks. Surfaces will be fabricated using either particles with hydrophilic and hydrophobic polymeric shells at their opposing sides (Janus particles) or mixtures of particles homogeneously coated with hydrophilic or hydrophobic polymers. By varying the size of the particles (50 – 1000 nm), surfaces featuring both chemical domain sizes from the nano- to the micrometer scale and a defined nano- to micro-rough topography can be prepared. The ability of the developed surfaces to inhibit adhesion of different bacterial species will be tested using high throughput bulk- as well as single cell-assays. The combination of these methods will facilitate the rapid and efficient identification of optimal particle parameter combinations, will help to further optimize the fouling-resistant performance of the designed surfaces and will gain mechanistic insight in the currently ill-defined working principle of amphiphilic surfaces. The experimental data will finally allow for developing a model to explain (and generalize) synergistic chemical and topographic effects that determine the non-adhesive performance of the particle-based surfaces. The project combines complementary expertise of two scientific groups in (i.) particle preparation and polymer/particle hybrid materials (Synytska) and (ii.) bio-functional polymeric materials and their use in the control of biointerfacial phenomena (Friedrichs/Werner). The ultimate goal of the proposed project is to pave the way for the rational design of robust and scalable fouling-resistant surfaces.
材料表面生物膜的形成--生物污垢--对广泛的应用和行业具有重大的经济影响。防污表面最近被证明可以从嵌段共聚物涂层中获得,这种涂层将亲水和疏水成分结合在一起,形成具有相反表面能的纳米级化学结构域(两亲性表面)。然而,在这种方法中,既不能有效地控制和/或改变地形(已知对生物污垢有很大影响的参数),也不能有效地控制和/或改变化学域的大小和间距。系统地研究两亲性表面的化学结构域大小和表面形貌对生物污垢的影响,可以揭示这些参数对生物附着过程的相互作用,并提供前所未有的污垢阻力水平。因此,拟议的项目旨在引入一种新的、可扩展的策略,以聚合物功能化胶体颗粒作为表面固定的构建块来设计具有受控污垢阻力的两亲性表面。表面将使用相对两侧具有亲水和疏水聚合物外壳的颗粒(Janus颗粒)或均匀涂覆亲水或疏水聚合物的颗粒的混合物来制造。通过改变颗粒的大小(50-1000 nm),可以制备出既具有从纳米到微米尺度的化学域尺寸,又具有从纳米到微米级粗糙表面的表面。所开发的表面抑制不同细菌种类黏附的能力将使用高通量批量和单细胞分析进行测试。这些方法的结合将有助于快速有效地识别最佳颗粒参数组合,有助于进一步优化所设计表面的防污性能,并将从机理上深入了解目前定义不清的两亲性表面的工作原理。实验数据最终将允许开发一个模型来解释(和概括)决定颗粒表面非粘附性的协同化学和地形效应。该项目结合了两个科学小组在(I)方面的互补专业知识。颗粒制备和聚合物/颗粒杂化材料(Synytska)和(Ii)生物功能聚合物材料及其在生物界面现象控制中的应用(Friedrichs/Werner)。拟议项目的最终目标是为合理设计坚固和可伸缩的防污垢表面铺平道路。

项目成果

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Privatdozentin Dr. Alla Synytska其他文献

Privatdozentin Dr. Alla Synytska的其他文献

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{{ truncateString('Privatdozentin Dr. Alla Synytska', 18)}}的其他基金

Synthesis and Self-Assembly of Stimuli-Responsive Core-Shell Janus Particles
刺激响应核壳Janus粒子的合成与自组装
  • 批准号:
    251031172
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Nanostructured smart polymer materials with adaptive / responsive adhesion properties
具有自适应/响应粘合性能的纳米结构智能聚合物材料
  • 批准号:
    65020956
  • 财政年份:
    2008
  • 资助金额:
    --
  • 项目类别:
    Research Grants

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Development of thermally stable and fouling-resistant polymeric membranes for SAGD produced water treatment
开发用于 SAGD 采出水处理的热稳定且抗污染的聚合物膜
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    556293-2020
  • 财政年份:
    2022
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Bioinspired Strategies for The Design of Anti-fouling Membranes: Combining Fouling Resistant Material with Novel Membrane Architecture
防污膜设计的仿生策略:防污材料与新型膜结构的结合
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  • 财政年份:
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Bioinspired Strategies for The Design of Anti-fouling Membranes: Combining Fouling Resistant Material with Novel Membrane Architecture
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  • 批准号:
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  • 财政年份:
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Development of thermally stable and fouling-resistant polymeric membranes for SAGD produced water treatment
开发用于 SAGD 采出水处理的热稳定且抗污染的聚合物膜
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Bioinspired Strategies for The Design of Anti-fouling Membranes: Combining Fouling Resistant Material with Novel Membrane Architecture
防污膜设计的仿生策略:防污材料与新型膜结构的结合
  • 批准号:
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  • 财政年份:
    2020
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STTR Phase I: Extremely fouling-resistant nanofiltration membranes treating organic-rich wastewater
STTR 第一阶段:极耐污染的纳滤膜处理富含有机物的废水
  • 批准号:
    1843847
  • 财政年份:
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Fouling resistant, freestanding zwitterionic polysulfones for osmotically driven membrane processes
用于渗透驱动膜工艺的防垢、独立式两性离子聚砜
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