心臓壁内で自発的に生起した高周波パルス状振動の伝搬特性のイメージングに関する研究

心壁内自发产生的高频脉冲振动传播特性成像研究

• 批准号: 16650120
• 负责人: 金井 浩
• 金额: $ 1.86万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Exploratory Research
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16650120/
• 关键词: 心臓疾患; 医用超音波工学; 心臓壁弾性特性; 位相差トラッキング法; 非侵襲計測; 組織性状診断; 心臓壁粘性特性; ラム波伝搬

本研究の目的は,心臓壁に沿って伝搬するパルス状振動の伝搬状態と伝搬速度を,100Hzまでの周波数帯域でイメージングするための超音波計測方法を確立し,高精度心臓疾患診断の可能性を探究するとともに,数百Hzまでの振動成分による医療診断という新しい研究分野の開拓する.下記の研究を行い,各項目に関して十分な成果を得た.1.水槽実験によるパルス状振動の伝搬速度の内圧依存性の検討(金井) シリコーンゴムによる弾性球殻を作製し,水槽実験において,パルス状振動が球殻壁上を伝搬する速度を超音波により計測した.ヒトの心臓壁に近い粘弾性特性をもつシリコーンゴムを用いたところ,ほぼヒトの心臓を同じ5m/s程度の伝搬速度が得られた.さらにヒトでは,大動脈弁の閉鎖タイミングにおいて内圧は急激に変化しているため,弾性球殻の内圧を変化させ,球殻を伝搬するパルス状波形の伝搬速度を計測したところ,内圧の低い場合に比較して,内圧を高くした場合に,伝搬速度が速くなる現象が得られた.ヒトに関して得られた結果を裏付けることができた.しかし,1つの波形伝搬中においても伝搬速度に変化があり,これがヒトの場合の伝搬速度の減少に対応する可能性もあることが見出された.2.伝搬速度の周波数分散の計測とイメージング(金井) 心臓壁内に設定した多数点でほぼ同時に計測されたパルス状振動波形を周波数解析することによって,100Hz成分までの各周波数成分に関する伝搬速度を決定できる計測法を開発し,伝搬速度に大きな速度分散性があることを確認した.これは,心臓の壁の粘弾性によるものであり,心筋の粘弾性を決定できる.3.心臓疾患患者への適用(西條・金井) 心疾患患者へ適用し,特に心筋梗塞患者の梗塞部位に,このパルス状振動が伝搬しないことを見出した.これは患部の同定にとって非常に重要な知見といえる.4.本研究の総括(金井) 以上,心筋梗塞による壊死領域の同定などの心臓疾患の診断を非侵襲で高精度に行うことが可能となり,臨床医学的な意義も大きいものと期待できる.

The purpose of this study is to establish an ultrasonic measurement method in the frequency band of 100 Hz for the transmission state and transmission speed of cardiac vibration along the wall, and to explore the possibility of high-precision diagnosis of cardiac diseases, and to explore new research areas for medical diagnosis of vibration components of hundreds of Hz. 1. Discussion on the internal pressure dependence of the transfer velocity of the circular vibration in the water tank; 2. Ultrasonic measurement of the transfer velocity of the circular vibration in the water tank. The viscosity characteristics of the heart wall of the heart are different from those of the heart wall. In addition, the internal pressure of the arterial system changes rapidly, the internal pressure of the spherical shell changes rapidly, and the transfer speed of the spherical shell is measured. In the case of low internal pressure, the transfer speed is measured in the case of high internal pressure. The result is that the number of people who have died is higher than the number of people who have died. 2. Measurement of the frequency dispersion of the transmission velocity. 3. Measurement of the frequency dispersion of the transmission velocity. 4. Measurement of the frequency dispersion of the transmission velocity. 5. Measurement of the frequency dispersion of the transmission velocity. 6. Measurement of the frequency dispersion of the transmission velocity. 7. Measurement of the frequency dispersion of the transmission velocity. 8. Measurement of the frequency dispersion of the transmission velocity. 8. Measurement of the frequency dispersion of the transmission velocity. 9. Measurement of the frequency dispersion of the transmission velocity. 8. Measurement of the frequency dispersion of the transmission velocity. 9. Measurement of the frequency dispersion of the transmission velocity. 8. Measurement of the frequency dispersion of the transmission velocity. 9. Measurement of the frequency dispersion of the transmission velocity. 9. Measurement of the frequency dispersion of the transmission velocity. 8. Measurement of the frequency dispersion of the transmission velocity. 9. Measurement of the frequency dispersion of the transmission velocity. 8. Measurement of the frequency dispersion of the transmission velocity. 9. Measurement of the frequency dispersion of the transmission velocity. 8. Measurement of the transmission velocity. 9. Measurement of the frequency dispersion of the transmission velocity. 8. Measurement of the transmission velocity. 9. Measurement of the transmission 100 Hz component and each frequency component are related to the determination of the transfer speed. The measurement method is developed and the transfer speed is large and the dispersion is confirmed. 3. Application to patients with heart disease (Nishijo Kanai) 4. This study covers more than (Kanai), cardiac infarction, cardiac disease, non-invasive diagnosis, high accuracy, clinical significance, and great expectations.

项目成果

超音波を用いた対象物の局所ひずみ発生装置

使用超声波的物体局部应变发生器

• 发表时间: 2004

Cross-Sectional Elasticity Imaging of Arterial Wall by Comparing Measured Change in Thickness with Model Waveform

通过比较测量的厚度变化与模型波形来进行动脉壁的横截面弹性成像

• 发表时间: 2005
• 期刊: Japanese Journal of Applied Physics 44
• 作者: Kamon;M.;Li;Y.;Endo;K.;Inui;T.;Katsumi;T;Masayasu Hata;Jiang Tang
• 通讯作者: Jiang Tang

Measurement of Shear Wave Propagation and Investigation of Estimation of Shear Viscoelasticity for Tissue Characterization ofthe Arterial Wall

剪切波传播的测量和动脉壁组织表征的剪切粘弹性估计的研究

• 发表时间: 2005
• 期刊: Journal of Medical Ultrasonics 32
• 作者: 長嶺駿;Kazuhiro Sunagawa
• 通讯作者: Kazuhiro Sunagawa

Detection of Lumen-Intima Interface of Posterior Wall for Measurement of Elasticity of the Human Carotid Artery

后壁管腔-内膜界面的检测用于测量人颈动脉的弹性

• 发表时间: 2004
• 期刊: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 51・1
• 作者: Hideyuki Hasegawa;Hiroshi Kanai;Yoshiro Koiwa
• 通讯作者: Yoshiro Koiwa

Electronic Staining : Elasticity Imaging of Atheroma with Transcutaneous Ultrasound

电子染色：经皮超声对动脉粥样硬化进行弹性成像

• 发表时间: 2004
• 期刊: Proceedings of the 18th International Congress on Acoustics Tu2・A1
• 作者: Hiroshi Kanai;Hideyuki Hasegawa
• 通讯作者: Hideyuki Hasegawa