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動脈壁上微小振動の伝搬特性と動脈硬化に伴う力学特性の局所的変化との関係の解明

阐明动脉壁上微小振动的传播特性与动脉硬化相关机械特性的局部变化之间的关系

基本信息

批准号：
06213205
负责人：
金井浩
金额：
$ 1.98万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
1994
资助国家：
日本
起止时间：
1994 至无数据
项目状态：
已结题

项目摘要

動脈硬化の診断では、動脈上の数mm以下の局部における弾性的特性に関する非侵襲的評価・解明が必要であるが、従来の診断法では、形態・変位情報に基づいて狭窄部位の同定はできるが、早期動脈硬化が現れ易い部位における局所の弾性率など力学的特性を直接評価できなかった。本研究では、独自に開発した、動脈壁上の振幅数十μmの微小振動を高精度に非侵襲計測できる計測装置を駆使し、壁弾性率の局所的変化に関する直接的評価を行って、管壁上の局所の微小振動伝搬特性と、動脈硬化症の早期段階における血管の力学的特性の局部的変化との関係を検討・調査した。その結果次の知見が得られた.1.シリコーンゴム管における基礎実験では、脈波は従来から知られているように顕著な内圧依存性を示したが,微小振動は設定圧の範囲では内圧依存性が見られなかった.2.軸方向引っ張り試験と内圧負荷試験によって得られた軸方向及び円周方向の弾性率の内圧依存性において、円周方向の弾性率は、上記の脈波伝搬速度の内圧依存性性と対応し、軸方向の弾性率は,加振時の微小振動伝搬速度と同様に内圧依存性は示さなかった.3.摘出したヒトの胸部大動脈を用いて微小振動伝搬特性を測定し、2点間距離が10〜20mm程度の局所的な診断で病理所見と一致した結果を得た.以上の結果から微小振動の伝搬速度計測法を実際のin-vivoの測定に適用すれば、有益な動脈硬化の指標が得られ,局所的な動脈硬化病変の早期発見が期待できることが示された.

The diagnosis of atherosclerosis is related to the non-invasive evaluation and explanation of the local characteristics of the artery within a few mm, the necessary diagnosis method, the morphological and positional information, the identification of the stenosis site, the local characteristics of the early atherosclerosis, and the mechanical characteristics. This study aims to investigate the relationship between the measurement device and the local changes in the mechanical properties of vessels in the early stages of atherosclerosis, and the direct evaluation of the relationship between the microvibration characteristics of local sites in the walls and the local changes in the mechanical properties of vessels in the early stages of atherosclerosis. The results are as follows: 1. The basic parameters of the vibration control system are as follows: 1. The internal pressure dependence is as follows: 2. The internal pressure dependence is as follows: 1. The internal pressure dependence is as follows: 2. The internal pressure dependence is as follows: 1. The internal pressure dependence is as follows: 2. The internal pressure dependence is as follows: 1. The internal pressure dependence is as follows: 2. The internal pressure dependence is as follows: 3. The internal pressure dependence is as follows: 1. The internal pressure dependence is as follows: 2. The internal pressure dependence is as follows: 3. The internal pressure dependence is as follows: 1. The internal pressure dependence is as follows: 2. The internal pressure dependence is as follows: 3. The internal pressure dependence is as follows: 1. The internal pressure dependence is as follows: 2. The internal pressure dependence is as follows: 3. The internal pressure dependence is as follows: 1. The internal pressure dependence is as follows: 2. The internal pressure dependence is as follows: 2. The internal pressure dependence is as follows: 3. The internal pressure dependence is as follows: 1. The internal pressure dependence is as follows: The above-mentioned internal pressure dependence of pulse transmission speed and the axial direction dependence are opposite, and the same internal pressure dependence of micro-vibration transmission speed during vibration application is also shown. 3. The micro-vibration transmission characteristics of the thoracic aorta were measured. The local diagnosis was made at a distance of 10 to 20 mm between 2 points, and the pathological findings were consistent with the results. These results indicate that the measurement of micro-vibration velocity is applicable in vivo, and useful indicators of atherosclerosis are obtained. Early detection of atherosclerosis is expected.

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

H.Kanai,K.Kawabe,M.TakanoR.Murata,N.Chubachi,Y.Koiwa: "New Method for Evaluating Local Pulse Wave Velocity by Measuring Vibrations on Arterial Wall" IEE Electronics Letters. 30. 534-536 (1994)

H.Kanai、K.Kawabe、M.TakanoR.Murata、N.Chubachi、Y.Koiwa：“通过测量动脉壁振动评估局部脉搏波速度的新方法”IEE 电子通讯。

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H.Kanai,T.Hori,N.Chubachi,T.Ono: "Delayed Block Transfer Function and its Application to Accurate Estimation of Transfer Function" IEEE Transactions on Signal Processing. 41. 1669-1684 (1994)

H.Kanai、T.Hori、N.Chubachi、T.Ono：“延迟块传输函数及其在传输函数精确估计中的应用”IEEE 信号处理汇刊。

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0
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通讯作者：

高野正彦,金井浩,中鉢憲賢,小岩喜郎,手塚文明,高橋光浩: "動脈硬化の局所診断のための血管壁上微小振動の計測と解析" 日本音響学会誌. 51. 174-181 (1995)

Masahiko Takano、Hiroshi Kanai、Kenken Chubachi、Yoshiro Koiwa、Fumiaki Tezuka、Mitsuhiro Takahashi：“用于动脉硬化局部诊断的血管壁微小振动的测量和分析”日本声学学会杂志 51. 174-181（1995 年）。 ) )