Management of evidence and conflict of interest in guidelines on early childhood allergy prevention and child nutrition (Conflict of Interest)

幼儿过敏预防和儿童营养指南中的证据和利益冲突管理（利益冲突）

• 批准号: 427399300
• 负责人: Professorin Dr. Eva Maria Bitzer
• 金额: --
• 依托单位: Institut für Alltagskultur, Bewegung und Gesundheit
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/427399300?language=en
• 关键词: Management; evidence; conflict; interest; guidelines

Early childhood allergy prevention (ECAP) is part of clinical practice guidelines (CPG) as well as food-based dietary guidelines (FBDG). CPG and FBDG are statements including recommendations intended to optimize health behaviour and patient care, which are informed by systematic reviews of existing evidence and an assessment of the benefits and harms of alternative care options. Considerable concern has been expressed by physicians, consumer groups, and other stakeholders about the quality of the processes supporting the development of CPGs and FBDGs, including a lack of transparency of development groups’ methodologies (particularly with respect to evidence quality) and unmanaged conflict of interests (COI). Active COI management is not employed regularly, and COI disclosures without management might not prevent guideline developers from biased advice. In addition, the prevalence of undisclosed COI is unknown. The study objectives are: 1) Assess the quality of guidelines on ECAP and child nutrition (CN) with emphasis on the management of scientific evidence and management of COI. 2) Quantify the amount of COI in guideline panel members and explore the association between COI and recommendation statements. 3) Explore ties between guideline panel members, ECAP and CN researchers, and research funding as a novel strategy to disclose COI.The projects‘ work program consists of three consecutive tasks.First, we will search comprehensively for national and international CPGs and FBDGs concerning ECAP and CN. With established methods we assess the quality of the guideline development process and the management of evidence and COI. Second, we will conduct an in-depth analysis of the association of COI with recommendation statements. We will analyze COI-disclosures with the recommendation statement as unit for analysis (e. g. how many recommendation statements within a guideline are authored by at least one panelist with COI), and with the panelist as unit of analysis (how often is a single panelist with COI engaged in recommendation statements). Third, we will explore the merits and feasibility of social network-analysis as a tool to elucidate ties between guideline panel members, researchers and research sponsors. We will examine if it can prove as an innovative and appropriate strategy to disclose COI.WP 1 is linked to “WP2-Living Systematic Review” (allows for a comparative analysis of studies included in guidelines and the living systematic review) and “WP3-Health Professionals” which will provide insights concerning the perception of COI by health professionals.

早期儿童过敏预防（ECAP）是临床实践指南（CPG）和基于食物的膳食指南（FBDG）的一部分。CPG和FBDG是包括旨在优化健康行为和患者护理的建议的声明，这些建议通过对现有证据的系统性审查和对替代护理方案的益处和危害的评估而获得。医生、消费者团体和其他利益相关者对支持CPG和FBDG开发的过程的质量表示了相当大的担忧，包括开发小组的方法缺乏透明度（特别是在证据质量方面）和未管理的利益冲突（COI）。主动的COI管理没有定期使用，没有管理的COI披露可能无法阻止指南开发人员提出有偏见的建议。此外，未披露的COI的患病率未知。 研究目的是：1）评估ECAP和儿童营养（CN）指南的质量，重点是科学证据管理和COI管理。2)量化指南小组成员的COI数量，并探索COI与推荐声明之间的关联。3)探索指南专家组成员、ECAP和CN研究人员之间的联系，以及作为披露COI的新策略的研究资金。本项目的工作计划包括三个连续的任务：首先，全面搜索有关ECAP和CN的国内和国际CPGs和FBDG。我们使用已建立的方法评估指南制定过程的质量以及证据和COI的管理。其次，我们将深入分析COI与推荐声明的关联。我们将以建议声明作为分析单位（例如：G.指南中有多少推荐声明是由至少一个具有COI的小组撰写的），以及以小组为分析单位（具有COI的单个小组参与推荐声明的频率）。第三，我们将探讨社会网络分析的优点和可行性，作为一种工具，阐明指导小组成员，研究人员和研究赞助商之间的关系。我们将研究它是否可以被证明是一种创新和适当的策略来披露COI。WP 1与“WP 2-活体系统评价”（允许对指南和活体系统评价中包含的研究进行比较分析）和“WP 3-卫生专业人员”相关联，后者将提供有关卫生专业人员对COI的看法的见解。