Chronic inflammasome activation in post-stroke recovery

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In our collaborative project, we want to understand how inflammasome activation is involved in chronic neuroinflammation after stroke. Expanding on our findings from the first funding period, we want to address now the mechanisms which lead contributing to chronic inflammasome activation and analyze the impact of inflammasome activation on long-range neuronal connectivity. Specifically, we will analyze dysfunctional lipid metabolism as a cause of inflammasome activation in immune and non-immune cells of the brain. We will focus on reorganization of the corticospinal tract after stroke to study the role of inflammasome activation on neuronal plasticity.