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Research on Dynamical Behavior of Biological Molecules in High Magnetic Field

强磁场中生物分子的动力学行为研究

基本信息

批准号：
01460042
负责人：
YAMAGISHI Akio
金额：
$ 3.33万
依托单位：
Research Center for Extreme Materials
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01460042/
关键词：
High magnetic field Biological system Human Blood Biological molecule Magnetic orientation Fibrin Magnetic Effect on biology Order parameter オ-ダ-パラメ-タ

项目摘要

Biological effects of magnetic fields are old but unsolved research subjects. By now very small number of papers reported physically clear results.We have carried out the research of magnetic orientation as physically understandable typical magnetic field effect on biological systems. The biological systems are mainly composed of diamagnetic materials and their anisotropy of diamagnetic susceptibility is of the order of 10^<-29> (emu/molecules). Theoretically this small value becomes large enough to orient in magnetic field when a number of molecules aggregate with their molecular axes in one direction. Based on these theoretical results, we investigated dynamical behavior of polymerization process of fibrinogen, one of the blood proteins, using 8T superconducting and 40T pulsed magnets.The main results are as follows.1. In the course of polymerization process, a period of first five to ten minutes is most important for magnetic orientation of fibers. If magnetic field is cut off during the period, the degree of orientation decreases gradually.2. During the period, fibers grow up in thickness as well as in length.3. We can guess and orientation process as follows. When fibers are small enough to rotate freely, magnetic orientation of fiber gel grows up as surrounding fibrin monomers aggregate with the oriented fibers.4. Pulsed field experiment shows that when fibers are too small their anisotropic susceptibilities are also too small to rotate.Another important result is the magnetic orientation of normal-human-red-blood-cells. They orient completely in 4 T steady magnetic field.

磁场的生物效应是一个古老而未解决的研究课题。到目前为止，只有极少数的论文报道了物理上明确的结果，我们已经开展了磁取向作为物理上可理解的典型磁场对生物系统的影响的研究。生物系统主要由抗磁材料组成，其抗磁磁化率的各向异性为10^<-29>（emu/分子）量级。理论上，当许多分子聚集在一个方向上时，这个小值变得足够大以在磁场中定向。在此基础上，我们利用8 T超导磁体和40 T脉冲磁体研究了血液蛋白纤维蛋白原聚合过程的动力学行为，主要结果如下：1.在聚合过程中，最初的5 ~ 10分钟对纤维的磁性取向最为重要。如果在此期间切断磁场，取向度逐渐降低。2.在此期间，纤维的长度和厚度都在增长.我们可以猜测和定位过程如下。当纤维足够小到可以自由旋转时，周围的纤维蛋白单体与取向的纤维聚集，纤维凝胶的磁性取向逐渐长大.脉冲场实验表明，当纤维太小时，它们的各向异性磁化率也太小而不能旋转。另一个重要结果是正常人红细胞的磁取向。它们在4 T稳恒磁场中完全取向.