The micro pump system which releases the neuro-transmitter as an artificial synapse.

微型泵系统将神经递质释放为人工突触。

• 批准号: 01460126
• 负责人: TSUCHIYA Kiich
• 金额: $ 3.46万
• 依托单位: Waseda University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01460126/
• 关键词: pump electrostatic; drug delivery system; ultrasonic; piezo electric; micro electromechanical system; neurotransmitter; ピエゾポンプ; シナップス; インタ-フェ-ス; 神経伝達物質; 化学情報情報伝達; 微小ポンプ

The purpose of this study is to develop an artificial synapse, i. e., a man-machine interface which mimics the signal transmission mechanism of the synapse in the nervous system. The artificial synapse is a kind of micro pump which ejects the neurotransmitter to the receptors in the membrane of the synapse.We selected two pumping mechanism. One was a pump which driven by the electrostatic energy. The other was a pump which driven by the vibration energy. The electrostatic driven pump had two problems, i. e., electrolysis and high energy consumption.As the pump which use the vibration energy, a piezoelectric pump and a bimorph pump were developed. Both pumps have a small chamber which covered by the polymer membrane at one side. The membrane has many tinY tunnels through which the neurotransmitter can pass and defuse into the body. When the piezoelectric disk or bimorph disk which attached to the other end of the chamber was actuated, the diffusion speed of the transmitter was remarkably increased. Therefore these pumps can control the release speed of the transmitter by changing the driving voltage and the duty factor. The piezoelectric pump can change the release speed from I to 8.7 times of that of basic speed. On the other hand, the bimorph pump can change it from 1 to 60 times of that of basic speed. It is concluded that the bimorph pump is the most promising device for the micro pump of the artificial synapse system.

本研究的目的是研制一种人工突触，即神经元突触。例如，模拟神经系统中突触的信号传输机制的人机接口。人工突触是一种将神经递质输送到突触膜上受体的微泵，我们选择了两种泵送机制。一个是由静电能驱动的泵。另一种是利用振动能量驱动的泵。静电驱动泵存在两个问题，即：例如，作为利用振动能量的泵，开发了压电泵和双晶片泵。两个泵都有一个小腔室，在一侧被聚合物膜覆盖。膜上有许多微小的隧道，神经递质可以通过这些隧道进入体内。当驱动腔体另一端的压电晶片或双压电晶片时，发射器的扩散速度显著提高。因此，这些泵可以通过改变驱动电压和占空因数来控制发射器的释放速度。压电泵可以将释放速度从1倍改变到基本速度的8.7倍。另一方面，双压电晶片泵可以在基本转速的1 ~ 60倍之间变化。结果表明，双压电晶片泵是最有前途的人工突触系统微泵器件。