Effect of collateral flow on ventricular arrhythmia during acute myocardial ischemia and reperfision

侧支血流对急性心肌缺血再灌注时室性心律失常的影响

• 批准号: 01480254
• 负责人: KUROIWA Akio
• 金额: $ 1.28万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01480254/
• 关键词: acute myocardial ischemia; reperfusion; ventricular arrhythmia; collateral flow; 急性病筋虚血; 急性重症虚血; 部分的再潅流; 冠動脈狭窄; dipyridamole; 心筋収縮力; 部分的再灌流; 持続性心室頻拍

In acutely ischemic nanine hearts, the incidence of ventricular arrhythmia is related to the development of collateral flow. Thus, we examined the effect of collateral flow on ventricular arrhythmia during acute myocardial ischemia and reperfusion.1)When dogs with poor development of collateral flow were used, pre-existing coronary stenosis caused the development of collateral flow and reduced the incidence of ventricular arrhythmia during subsequent occlusion.2)The technique of retrograde blood flow(RBF)decreases collateral flow into the ischemic myocardium, and to cause severe myocardial ischemia in dogs. During retrograde blood flow, the severity of ischemia was great, and the incidences of ventricular premature beats and ventricular tachycardia(VT)were high, but that of ventricular fibrillation(VF)was not high. Thus, RBF can be used to examine occulusive and reperfusion ventricular arrhythmia in dogs.3)When the antecedent ischemia was 10 min RBF, reperfusion VF was not prevented by partial reperfusion.4)We examined the electrophysiologic changes before an onset of ventricular tachyarrhythmias during partial reperfusion followina 20 min RBF. During partial reperfusion, slight improvement in fractionation induced sustained VT, and an occurrence of new deflections induces non-sustained VT degenerating VF.

在急性缺血的小心脏中，室性心律失常的发生与侧支循环的发展有关。因此，我们研究了急性心肌缺血和再灌注期间侧支血流对室性心律失常的影响。1）当使用侧支血流发育不良的犬时，预先存在的冠状动脉狭窄引起侧支血流的发展，并降低随后闭塞期间室性心律失常的发生率。2）逆行血流（RBF）技术减少了进入缺血心肌的侧支血流，并导致犬严重心肌缺血。逆行血流时心肌缺血严重，室性早搏和室性心动过速（VT）发生率高，但室颤（VF）发生率不高。3）缺血10 min时，部分再灌注不能阻止室性心律失常的发生; 4）缺血20 min后部分再灌注，观察室性心律失常发生前的电生理变化。在部分再灌注期间，分级的轻微改善诱导持续性VT，并且新偏转的发生诱导非持续性VT退化VF。

项目成果

Hayakawa T,Nagamoto Y,Ninomiya K,Abe S,Fukumoto T,Kuroiwa A.: "Effects of heart rate and diltiazem hydrochloride on alternans of ST segment elevation and ventricular arryhythmia during acute myocardial ischemia in dogs." Cardiovasc Res. 23. 520-528 (1989)

Hayakawa T，Nagamoto Y，Ninomiya K，Abe S，Fukumoto T，Kuroiwa A.：“心率和盐酸地尔硫卓对狗急性心肌缺血期间 ST 段抬高和室性心律失常交替的影响。”

Fujita M,Nagamoto Y,Furuno Y,Ohkita T,Kuroiwa A.: "Effect of pre-existing four hour coronary stenosis on ventricular arrhythmias during a subsequent 10 minute occlusion in dogs." Cardiovasc. 24. 896-902 (1990)

Fujita M、Nagamoto Y、Furuno Y、Ohkita T、Kuroiwa A.：“在狗的随后 10 分钟闭塞期间，预先存在的 4 小时冠状动脉狭窄对室性心律失常的影响。”

Abe S,Nagamoto Y,Fukuchi Y,Hayakawa T,Kuroiwa A.: "Relationship of alternans of monophasic action potential and conduction delay inside the ischemic border zone to serious venticular arrhythmia during acute myocardial ischemia in dogs." Am Heart J.117. 12

Abe S，Nagamoto Y，Fukuchi Y，Hayakawa T，Kuroiwa A.：“犬急性心肌缺血期间缺血边界区内单相动作电位和传导延迟的交替与严重室性心律失常的关系”。

T.Ohkita,Y.Nagamoto,M.Kuriyama,A.Kuroiwa: "Ventricular fibrillation during partial reperfusion following severe myocardial ischemia." J Electrocardiol. 23. 347-358 (1990)

T.Ohkita、Y.Nagamoto、M.Kuriyama、A.Kuroiwa：“严重心肌缺血后部分再灌注期间的心室颤动。”

Nagamoto Y,Fujita M,Furuno Y,Ohkita T,Kuroiwa A.: "Myocardial blood flow,alternans of ST segment elevation,conduction delay and ventricular arrhythmia during acute myocardial ischemia with and without retrograde blood flow in canine hearts." Jpn Circ.J.55

Nagamoto Y、Fujita M、Furuno Y、Ohkita T、Kuroiwa A.：“犬心脏急性心肌缺血时的心肌血流、ST 段抬高交替、传导延迟和室性心律失常。”