Glomerular and Tubular Function in the Recovering Kidney

肾脏恢复中的肾小球和肾小管功能

• 批准号: 10587898
• 负责人: SCOTT Culver THOMSON
• 金额: $ 43.76万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10587898
• 关键词: Ablation; Acute; Acute Renal Failure with Renal Papillary Necrosis; Affect; Amino Acids; Angiotensins; Animals; Area; Behavior; Blood Pressure; Chronic Kidney Failure; Clinical; Clinical Trials; Compensation; Coupling; Creatinine clearance measurement; Data; Diagnosis; Diet; Disease; Electrolytes; Equilibrium; Event; Evolution; Excretory function; Feedback; Future; Glomerular Capillary; Glucose Transporter; Heterogeneity; Homeostasis; Hospitals; Human; Hypersensitivity; Hypoxia; Impairment; Incidence; Individual; Infarction; Infusion procedures; Injury; Injury to Kidney; Intervention; Ischemia; Kidney; Knowledge; Left; Liquid substance; Mathematics; Measures; Medical; Meta-Analysis; Metabolic stress; Metabolism; Methods; Micropuncture; Microscopic; Modeling; Nephrons; Outcome; Patients; Physiological; Physiology; Predisposition; Randomized; Rattus; Recovery; Regulation; Renal Blood Flow; Renal Mass; Renal function; Renin-Angiotensin System; Reperfusion Therapy; Research; Research Personnel; Saline; Sodium-Restricted Diet; Stress Tests; Techniques; Testing; Time; Tubular formation; Urine; absorption; base; design; dietary; experimental study; healing; hemodynamics; human model; human subject; improved; inhibitor; injured; preservation; pressure; prevent; response

Project Summary Abstract This research will provide information on the inner working of the kidney as it recovers from acute injury. Recovery of the kidney from acute injury is often incomplete and leaves behind a kidney that is prone to subsequent permanent decline due to physical and metabolic stresses of trying to compensate for incomplete healing. Ideally, targeted intervention would hasten recovery from acute kidney injury and diminish its long- term consequences. However, major knowledge gaps in the area of renal recovery currently preclude a rational approach to treatment. Knowledge gaps include the physical reason why the injured kidney appears to filter less fluid, the vulnerability of the injured kidney to be further injured by changes in blood pressure, or whether standard medical treatments or prescribed diets are helpful or harmful in patients recovering from kidney injury. Kidney features that are observed at the whole-kidney level emerge from events at the microscopic level and treatments have their direct effect at the microscopic level. However, there can be multiple combinations of microscopic events that could account for a given observation at the whole-kidney level. Therefore, microscopic behavior cannot be deduced from whole-kidney behavior and must be observed directly. This cannot be done in humans but can be done in rat models of human kidney injury using specialized techniques uniquely available to the investigators. Through these methods, this research will determine the effects of simple maneuvers on multiple internal variables thereby establishing boundary conditions for efficient design of future clinical trials in the field of kidney recovery.

项目摘要 这项研究将提供有关肾脏从急性损伤中恢复时内部工作的信息。 肾脏从急性损伤中的恢复通常是不完全的，并且留下了易于发生急性损伤的肾脏。 由于试图补偿不完全的身体和代谢压力， 治愈理想情况下，有针对性的干预将加速急性肾损伤的恢复，并减少其长期的损害。 长期后果。然而，目前在肾脏恢复领域的主要知识缺口排除了合理的治疗方法。 治疗方法。知识差距包括为什么受伤的肾脏似乎过滤较少的物理原因 液体，受伤的肾脏的脆弱性，以进一步伤害血压的变化，或是否 标准的医学治疗或规定的饮食对从肾损伤中恢复的患者是有益的还是有害的。 在整个肾脏水平上观察到的肾脏特征来自微观水平上的事件， 治疗的直接效果是在微观层面。然而，可以存在以下各项的多种组合： 可以解释在全肾水平上的给定观察结果的微观事件。因此，微观 行为不能从全肾行为推断，必须直接观察。这不能在 但是可以在人肾损伤的大鼠模型中使用唯一可用的专门技术来完成 给调查人员通过这些方法，本研究将确定简单机动对 多个内部变量，从而为未来临床试验的有效设计建立边界条件 在肾脏恢复领域。