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Coronary reperfusion and left ventricular function

冠状动脉再灌注和左心室功能

基本信息

批准号：
01480252
负责人：
KATORI Ryo
金额：
$ 1.6万
依托单位：
Kinki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01480252/
关键词：
myocardial infarction coronary artery occlusion myocardial ischemia collateral circulation NMR myocardial blood flow thrombolysis left ventricular function 心エコ-図 ATP Stunned myocardium ウロキナ-ゼ stunned myocardial

项目摘要

1. Experiments of coronary occlusion and reperfusion : We measured regional myocardiall contractility and myocardial blood flow by the colored microsphere method in dogs which underwent a breaf (15 min) occlusion of the left anterior descending branch. In order to examine the stunned myocardium positive inotropic intervention of an atrial premature beat was performed before, during and after the occlusion. The stunned myocardium occured only in the myocardium with less 20 % collateral circulation.2. NMR determination of ischemic myocardial metabolism under breaf global ischemia in rabbit hearts : The experiment was performed by using the Langendorf method with artificial blood, FC43. Rabbit hearts underwent 15 min global ischemia with suspension of coronary artery supply in a NMR chamber and ATP, CrP, Pi and pH were measured continuously before, during and after ischemia. Adminstration of methylpredonisolone before ischemia significantly improved the post-ischemic derangement of ATP and developed tension of the left ventricle. The effects were not observed by post-ischemic administration. This was considered to be due to membrane stabilizing action of this drug.3. Clinical studies in myocardial infarction patients : Recanalization of occluded infarct-related- coronary artery with urokinase prevented the expansion and thinning of the infarcted myocardium observed 4 and 5 days later. The patients with thrombolysis also had more cardiac output than the other patients did. In the study of recovery phase, it is concluded that exercise-induced ST-segment elevation is induced by electrophysiological difference between infarction area and non-infarction area which is resulted from stimulation of beta-adrenergic receptors.

1.冠状动脉闭塞和再灌注实验：我们采用彩色微球法测量了对左前降支进行短时间（15分钟）闭塞的狗的局部心肌收缩力和心肌血流量。为了检查心力衰竭的心肌，在闭塞之前、期间和之后进行房性早搏的正性肌力干预。心肌顿抑仅发生在侧支循环不足20%的心肌中。2．兔心脏全缺血状态下缺血心肌代谢的NMR测定：本实验采用Langendorf法，采用人工血液FC43进行。兔心脏经历 15 分钟的整体缺血，并在 NMR 室中暂停冠状动脉供应，并在缺血之前、期间和之后连续测量 ATP、CrP、Pi 和 pH。缺血前给予甲基泼尼松龙可显着改善缺血后 ATP 紊乱并产生左心室张力。缺血后给药未观察到效果。这被认为是由于该药物的膜稳定作用。3．心肌梗塞患者的临床研究：用尿激酶使闭塞的梗塞相关冠状动脉再通，可防止4天和5天后观察到的梗塞心肌的扩张和变薄。溶栓患者的心输出量也高于其他患者。在恢复期的研究中，认为运动引起的ST段抬高是由于梗塞区和非梗塞区之间的电生理差异引起的β-肾上腺素受体的刺激而引起的。