Studies on the Inhibitory Effect of Blood Transfusion Against Anti-Tumor Immunity

为分析输血对小鼠存活率影响的机理，进行了小鼠体内实验研究。接受同种异体血液的小鼠的存活率显著低于同基因输注或生理盐水输注的对照组（C57 BL/10：p<0.05，BALB/C：p<0.01）。输注淋巴细胞组的存活率低于输注血浆或红细胞组（P<0.05）。而在体外实验中，异基因供者输注组的抗X5563 CTL（P<0.05）、TNP-CTL（P<0.01）和NK（P <0.05）的应答均显著低于对照组和同基因供者输注组。此外，我们证明了抑制CTL活性是由抑制细胞介导的。

To analyze the mechanism on the effect of blood transfusion, we studied on survival rate in mice in vivo experiments. Mice that received allogenic blood had significantly worse survival rate than either syngenic-transfuued or saline-infused control groups (C57BL/10 : p<0.05, BALB/C : p<0.01). A transfusion of lymphocytes reduced survival rate in comparison with a transfusion of plasma or RBC (P<0.05). On the other hand, in vitro experiments, the responses of the greop transfused with allogenic donors were significantly lower than responses of control or syngenic transfused group, in either anti-X5563 CTL (P<0.05), TNP-CTL (p<0.01), or NK (p<0.05). Furthermore, we demonstrated that the suppression of CTL activity was mediated by suppressor cells.