A Pathological Study of Epithelium in Severe Cornero-Conjunctival Diseases.

结膜组织的侵袭一直是眼表疾病最难预防的并发症。在本研究中，角膜上皮细胞，特别是角膜缘细胞，进行了培养。很明显，不仅边缘附近的细胞分裂活跃，而且迁移也比其他部分的细胞活跃得多。此外，那些来自颞叶边缘的细胞可靠地显示了这一趋势。从这个角度来看，角膜缘组织被实验性地移植到新生血管的角膜上。结果表明，牛磺酸和透明质酸具有与角膜上皮细胞一样的再上皮化能力。牛磺酸和透明质酸对角膜上皮损伤的修复作用得到了实验验证，为临床应用这两种药物提供了可能。对于严重的间质障碍，采用结膜拍打的方法达到了预期的效果；快速上皮化，炎症消退。结膜CALT的发现为我们带来了与眼表防御系统有关的最显著的信息，结合免疫学研究，对接种的淋巴细胞进行了组织学观察。还研究了基质细胞对异物的反应和浅上皮粘蛋白的细节。

Invasion of conjunctival tissue of ocular surface disorders has been known as the most difficult complication to prevent its progress.In this study, corneal epithelial cells especially limbal cells, were incubated. And it became clear that not only the segmentation but also the migration of the cells near the limbus were much more active than those cells from other portions. Moreover, those cells from the temporal periphery reliably showed this tendency. From this point of view, limbal tissue were experimentally transplanted to the neovascularised corneas. The results showed the excellent re-epithelization as likely as corneal epithelial cells.The effects of epithelial wound healing of Taurine and hyaluronic acid were experimentally certified and those results led us the possibility of clinical use with these drugs. Conjunctival flapping to the severe stromal disorders used to show the good enough results which we expected ; Quick re-epithelization, settlements of inflammation.The most remarkable information related to the defense system in ocular surface was brought us by the finding of CALT in conjunctiva with immunological studies in which the inoculated lymphocytes were observed histologically.The stromal cell reactions to the foreign bodies and the details of mucin layers on the superficial epithelium were also studied.