The Effects of Sedatives and Somatosensory Evoked Potentials

镇静剂和体感诱发电位的影响

• 批准号: 01480478
• 负责人: AMEMIYA Yoshihiro
• 金额: $ 4.48万
• 依托单位: Tsurumi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01480478/
• 关键词: Sedative; Indicator of sedation level; Benzodiazepine; Diazepam; Flunitrazepam; Midazolam; Blood gas; Intravenous sedation; ミダゾラム; ベンゾジアゼピン; ジアゼピン; 静脈内鎮静薬

This study was designed to investigate the possibility of changes in blood gas tensions as an indicator of sedation level induced by benzodiazepines. The subjects of this study were healthy young volunteers. After catheters had been inserted into the radial artery, median vein and right atrium, they were injected with 0.02mg/kg of flunitrazepam or 0.3 mg/kg of diazepam over 2 min. Midazolam was also injected rapidly or slowly at the rate of 0.5 mg/30sec or 0.25 mg/30 sec, respectively. Then the following variables were measured for 120 min ; arterial, venous and mixed PO2, PCO2, pH, pulse rate, cardiac output and stroke volume.As a result, three benzodiazepines were found to decrease arterial and mixed PO2, pH and venous PCO2, and to increase arterial and mixed PCO2, venous PO2 and pH. In comparison among drugs, flunitrazepam changed the values more intensely and longer than other two drugs. And though the changes in values lasted longer than the duration of sedation in flunitrazepam i … More njected groups, they did not in other two group. As to midazolam injected groups, when slow and rapid injection was compared, the changes in values were remarkable in the rapid group, which showed marked sedation.These results indicate that though the changes in degree of blood gas tensions were different depend on drug, the sedation level might correlate with the changes in degree of tensions within each drug. Further investigations should be necessary to clarify the correlation between them.Though at first the somatosensory evoked potential (SEP) elicited by human tooth pulp stimuli were scheduled to indicate the sedation level, the imperfect equipment made the study difficult. So this time cardiovascular changes were studied in combination with the changes in blood gases. We will investigate the possibility of SEP as an indicator of sedation level as well as the blood gas tensions using a signal processor 7T18 (Nihondenki Sanei Co.), which was newly equipped in 1991 by the Bounty for the Private School. Less

本研究旨在探讨血气分析作为苯二氮卓类镇静水平指标的可能性。研究对象为健康青年志愿者。将导管插入桡动脉、正中静脉和右心房后，在2分钟内注射氟硝西泮0.02 mg/kg或地西泮0.3 mg/kg，并分别以0.5 mg/30秒或0.25 mg/30秒的速度快速或缓慢注射咪达唑仑。然后测量以下变量120 min ;结果表明，三种苯二氮卓类药物均能降低动脉、静脉和混合氧分压（PO_2）、pH和静脉PCO_2，升高动脉、静脉和混合PCO_2、pH和每搏输出量。氟硝西泮对上述值的改变较其他两种药物更强烈、持续时间更长。虽然氟硝西泮i组的数值变化持续时间长于镇静持续时间， ...更多信息 注射组，其余两组均未注射。在咪达唑仑注射组中，快速注射组与慢速注射组比较，其数值变化显著，表现出明显的镇静作用，提示虽然不同药物的血气变化程度不同，但镇静作用的强弱可能与各药物的血气变化程度有关。虽然最初计划用人牙髓刺激诱发的体感诱发电位（SEP）来指示镇静水平，但由于设备的不完善，给研究带来了困难。因此，这一次心血管变化与血气变化相结合进行了研究。我们将使用信号处理器7 T18（Nihondenki Sanei Co.）研究SEP作为镇静水平以及血气紧张度的指标的可能性，1991年，由邦蒂为私立学校新装备的。少

项目成果

I NOGUCHI, K KANEKO, K MIUBA, S SEKITA, Y AMEMIYA: "Changes in blood gas tensions and cardiovascular variables with the injection of flunitrazepam" ANESTHESIA PROGRESS. Vol 39. (1992)

I NOGUCHI、K KANEKO、K MIUBA、S SEKITA、Y AMEMIYA：“注射氟硝西泮后血气压力和心血管变量的变化”麻醉进展。

野口いづみ、三浦一恵、雨宮義弘、ほか: "ベンゾジアゼピン系薬物が動静脈血液ガスに及ぼす影響" 日本歯科麻酔学会雑誌.

Izumi Noguchi、Kazue Miura、Yoshihiro Amemiya 等：“苯二氮卓类药物对动静脉血气的影响”日本牙科麻醉学会杂志。

Izumi Noguchi,Kazumasa Kaneko,Kazue Miura,Shunsuke Sekita,Yoshihiro Amemiya: "Chauges in Blood Gas Tentions and Cardiousecular Variables with the Injection of Flunitrazepain" Anesthesia Progress. Vol39. (1992)

Izumi Noguchi、Kazumasa Kaneko、Kazue Miura、Shunsuke Sekita、Yoshihiro Amemiya：“注射氟硝西平可改变血气张力和心血管变量”麻醉进展。